Lenvatinib Impurity 4 CAS 417719-45-0
| CAS No. | 417719-45-0 |
| Molecular Formula | C19H17ClN4O4 |
| Molecular Weight | 400.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Lenvatinib Impurity 4 (CAS 417719-45-0) is a certified pharmaceutical impurity reference standard with the molecular formula C19H17ClN4O4 and a molecular weight of 400.82 g/mol.
Structurally, Lenvatinib Impurity 4 (C19H17ClN4O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 400.82 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H17ClN4O4 |
| Molecular Weight | 400.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Lenvatinib Standards
- Lenvatinib Impurity 172 (CAS CATO-C4X-1140172)
- Lenvatinib Impurity 180 (CAS CATO-C4X-1140180)
- Lenvatinib Impurity 43 (CAS 1882873-21-3)
- Lenvatinib Impurity 1 (CAS 417714-14-8)
- Lenvatinib Impurity 89 (CAS CATO-C4X-114089)
- Lenvatinib Impurity 30 (CAS 417717-04-5)
- Lenvatinib Impurity 42 (CAS 2733083-03-7)
- Lenvatinib Impurity 87 (CAS CATO-C4X-114087)
Recommended Standards
- Avanafil Impurity 4 (CAS 1452128-53-8)
- 5-Chloro-2-fluoro-N-{1-[(5-phenyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-3-yl}benzamide (CAS 1396684-08-4)
- Indoxacarb Impurity 4 (CAS 170917-89-2)
- 3-[1-(3-Chloro-4-fluorobenzoyl)piperidin-4-yl]-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775458-46-2)
- Hydroxyzine Impurity 1 (CAS 628-89-7)
- Chloroquine Impurity 10 (CAS CATO-C4X-210410)
- Tiamulin EP Impurity E (CAS 113323-39-0)
- 3'-Acetyl-[1,1'-biphenyl]-4-carboxylicacid (CAS 199678-04-1)
- ethyl[(4-methoxyphenyl)(pyridin-3-yl)methyl]amine (CAS 1153032-83-7)
- 3-(Benzylamino)-4-((2-cyanophenyl)amino)-4-oxobutanoic acid (CAS 1022917-21-0)
- Pemetrexed Impurity 64 (CAS 65906-68-5)
- 2-(N-Boc-amino)-3-prop-2-ynylsulfanyl-propionic acid (CAS 1260119-25-2)
- tert-butyl N-[2,2,2-trifluoro-1-(hydroxymethyl)ethyl]carbamate (CAS 126536-02-5)
- Neuropeptide GE (CAS 134748-04-2)
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