Lenvatinib Impurity 51 CAS 417723-07-0
| CAS No. | 417723-07-0 |
| Molecular Formula | C18H15ClN2O4 |
| Molecular Weight | 358.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Lenvatinib Impurity 51 (CAS 417723-07-0) is a certified pharmaceutical impurity reference standard with the molecular formula C18H15ClN2O4 and a molecular weight of 358.78 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Lenvatinib Impurity 51 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 358.78 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Lenvatinib Impurity 51 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H15ClN2O4 |
| Molecular Weight | 358.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Lenvatinib Standards
- Lenvatinib Impurity 163 (CAS CATO-C4X-1140163)
- Lenvatinib Impurity 162 (CAS CATO-C4X-1140162)
- Lenvatinib Impurity 100 (CAS 2712290-12-3)
- Lenvatinib Impurity 57 (CAS CATO-C4X-114057)
- Lenvatinib Impurity 143 (CAS CATO-C4X-1140143)
- Lenvatinib Impurity 146 (CAS CATO-C4X-1140146)
- Lenvatinib impurity 167 (CAS CATO-C4X-1140167)
- Lenvatinib impurity 168 (CAS CATO-C4X-1140168)
Recommended Standards
- N-(3-(2-chloroacetyl)-2,5-dimethyl-1H-pyrrol-1-yl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide (CAS 790271-02-2)
- Tolvaptan Impurity 20 (CAS 137982-91-3)
- 4-(5-Chloro-2-methoxyanilino)-6-methoxy-3-quinolinecarboxylic acid (CAS 941233-83-6)
- Quizalofop-Methyl (CAS 76578-13-7)
- Amoxicillin Impurity 28 (CAS 37727-80-3)
- Alogliptin Impurity 16 (CAS 1430222-09-5)
- Temozolomide Impurity 22 (CAS 1114912-01-4)
- 5-ethyl-2-isopropyl-furan-3-amine;hydrochloride (CAS 2567560-19-2)
- Tert-butyl 6-oxo-2,5-diazaspiro[3.5]Nonane-2-carboxylate (CAS 2375528-15-5)
- Methyl 2-(methanesulfonyloxy)acetate (CAS 23550-26-7)
- 7,8,9,10-Tetrahydro-1H-pyrazolo[3',4':4,5]pyrimido[1,2-a]azepin-4(6H)-one (CAS 23942-31-6)
- (1r)-1-(5-Bromothiophen-2-yl)ethan-1-ol (CAS 224622-12-2)
- 5,5-Dimethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (CAS 723286-97-3)
- Peptide 431 (CAS CATO-CPTD788431)
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