Olaparib Impurity 14 CAS 420846-72-6
| CAS No. | 420846-72-6 |
| Molecular Formula | C16H12N2O3 |
| Molecular Weight | 280.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Olaparib Impurity 14 (CAS 420846-72-6, C16H12N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Olaparib Impurity 14 (C16H12N2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Olaparib Impurity 14 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H12N2O3 |
| Molecular Weight | 280.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 2 |
Related Olaparib Standards
- Olaparib Impurity 109 (CAS CATO-C4X-1135109)
- Olaparib Impurity 12 (CAS 1021298-68-9)
- Olaparib Impurity 102 (CAS 1806327-68-3)
- Olaparib Impurity 105 (CAS 477535-39-0)
- Olaparib Impurity 93 (CAS 1379332-00-9)
- Olaparib Impurity 58 (CAS CATO-C4X-113558)
- Olaparib Impurity 59 (CAS CATO-C4X-113559)
- Olaparib Impurity 89 (Mixture E&Z) (CAS CATO-C4X-113589)
Recommended Standards
- Erlotinib Impurity 29 (CAS CATO-C4X-106929)
- Methotrexate EP Impurity L (CAS 52980-68-4)
- Erlotinib Impurity 28 (CAS CATO-C4X-106928)
- Methotrexate Impurity 31 (CAS CATO-C4X-115431)
- Tivozanib Impurity 6 (CAS CATO-C4X-34006)
- Molsidomine EP Impurity B (CAS 59-89-2)
- Mizolastine impurity 14 (CAS CATO-C4X-200614)
- 1-Nitroso-Piperazine TFA salt (CAS CATO-C4X-249330)
- 5-Chloro-2-hydrazineyl-4-tosylthiazole (CAS 297142-57-5)
- Lercanidipine Impurity 74 (CAS CATO-C4X-136474)
- 3-Methyl-N-((tetrahydro-2h-pyran-4-yl)methyl)aniline (CAS 1249858-06-7)
- [2-(dimethylamino)ethyl](2-methylpropyl)amine (CAS 926205-56-3)
- Ethyl 2-(Benzylamino)-4-methyl-1,3-thiazole-5-carboxylate (CAS 15087-95-3)
- Semaglutide Impurity 186 (CAS CATO-C4X-2226186)
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