Olaparib Impurity 105 CAS 477535-39-0
| CAS No. | 477535-39-0 |
| Molecular Formula | C7H3Br2FO |
| Molecular Weight | 281.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Olaparib Impurity 105 (C7H3Br2FO) is characterized by a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Olaparib Impurity 105 (CAS 477535-39-0) is a certified pharmaceutical impurity reference standard with the molecular formula C7H3Br2FO and a molecular weight of 281.90 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Olaparib Impurity 105 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H3Br2FO |
| Molecular Weight | 281.90 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Br-containing |
Related Olaparib Standards
- Olaparib Impurity 102 (CAS 1806327-68-3)
- Olaparib Impurity 93 (CAS 1379332-00-9)
- Olaparib Impurity 58 (CAS CATO-C4X-113558)
- Olaparib Impurity 59 (CAS CATO-C4X-113559)
- Olaparib Impurity 89 (Mixture E&Z) (CAS CATO-C4X-113589)
- Olaparib Impurity 14 (CAS 420846-72-6)
- Olaparib Impurity 37 (CAS 1423030-11-8)
- Olaparib Impurity 76 (CAS CATO-C4X-113576)
Recommended Standards
- 3,6-Dibromo-2-fluorobenzaldehyde (CAS 870703-68-7)
- (4-(2-Borono-3-(methoxymethoxy)phenyl)butyl)boronic acid (CAS 502635-30-5)
- 3,5-Dibromo-2-fluorobenzaldehyde (CAS 477535-40-3)
- 9,9-Dimethyl-9H-fluorene-2,7-diboronic Acid (CAS 866100-14-3)
- Oclacitinib impurity 1 (CAS CATO-C4X-30181)
- Sitagliptin impurity 114 (CAS CATO-C4X-1144114)
- Leucogen Impurity 13 (CAS CATO-C4X-288913)
- 2,3,5,6-Tetrakis(4-bromophenyl)pyrazine (CAS 52889-50-6)
- 3-(Difluoromethoxy)-4-iodobenzoic acid (CAS 1695687-68-3)
- N-(1-(4-Nitrophenyl)-1H-pyrazol-4-yl)-2-phenylacetamide (CAS 62537-79-5)
- 5-(1-Butylpiperidin-2-yl)-2-isopropoxypyridine (CAS 1352536-45-8)
- (2R,3R,4R,5R)-2-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (CAS 1044589-83-4)
- 1-(2-Cyclopropyl-5,6-dimethylpyrimidin-4-yl)-1,4-diazepane (CAS 1713639-67-8)
- Semaglutide Impurity 187 (CAS CATO-C4X-2226187)
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