Diltiazem Impurity N29 Hydrochloride CAS 42399-54-2
| CAS No. | 42399-54-2 |
| Molecular Formula | C22H26N2O4S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Diltiazem Impurity N29 Hydrochloride (CAS 42399-54-2, C22H26N2O4SHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Diltiazem Impurity N29 Hydrochloride (C22H26N2O4SHCl) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H26N2O4S HCl |
| Molecular Weight | 450.98 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1969 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Diltiazem Standards
- Diltiazem EP Impurity A HCl (CAS 103532-27-0)
- Diltiazem EP Impurity A HCl (CAS 111188-71-7(free base))
- Diltiazem D4 (CAS 112259-41-3)
- Diltiazem USP Related Compound H HCl (CAS 115992-91-1(Free Base))
- Diltiazem EP Impurity H HCl (CAS 115992-91-1(free base))
- Diltiazem Impurity 9 (CAS 116050-35-2)
- Diltiazem Impurity 23 (CAS 119009-50-6)
- Diltiazem-d3 Hydrochloride (CAS 1217623-80-7)
Recommended Standards
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- Dutasteride EP Impurity F (CAS CATO-C4X-11036)
- 3-Methylimidazo[1,5-a]pyridin-1-amine (CAS 344327-06-6)
- N-Methyl 4,5-dibromo-2-methoxyaniline (CAS 1187386-09-9)
- 3-{[4-(Hydroxymethyl)-2-methoxyphenoxy]methyl}benzoic acid (CAS 693815-64-4)
- 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiazolo[5,4-b]pyridine (CAS 1580489-60-6)
- 2-Methylbenzofuran-3-carbaldehyde (CAS 55581-61-8)
- 5-(3-Fluorophenyl)-3-(m-tolyl)-1H-1,2,4-triazole (CAS 1208383-49-6)
- Liraglutide(14-22)TFA Salt (CAS CATO-C4X-199212)
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