Aprepitant Impurity 75 CAS 240489-98-9
| CAS No. | 240489-98-9 |
| Molecular Formula | C10H6F6O |
| Molecular Weight | 256.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Aprepitant Impurity 75 (CAS 240489-98-9, C10H6F6O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Aprepitant Impurity 75 (C10H6F6O) contains a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H6F6O |
| Molecular Weight | 256.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
Related Aprepitant Standards
- Aprepitant Impurity 34 (CAS 30071-93-3)
- Aprepitant impurity 28 (CAS 479679-98-6)
- Aprepitant Impurity 32 (CAS 225920-05-8)
- Aprepitant Impurity 33 (CAS 1265177-56-7)
- Aprepitant Impurity 38 (CAS 127852-28-2)
- Aprepitant Impurity 45 (CAS 364-47-6)
- Aprepitant Impurity 76 (CAS CATO-C4X-114176)
- Aprepitant impurity 50 (CAS 349-59-7)
Recommended Standards
- 3-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-ol (CAS 1000802-50-5)
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- (1S,4R,5S,6R)-4,5,6-Trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl dihydrogen phosphate (CAS 1264709-36-5)
- N-t-Butyl 3-bromobenzamide (CAS 42498-39-5)
- Atorvastatin Impurity 100 (CAS CATO-C4X-1132100)
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- Indometacin Impurity 37 (CAS CATO-C4X-147037)
- 3(2H)-benzofuranone, 5-bromo-7-methoxy- (CAS 951800-40-1)
- 4-bromo-5-fluoro-1h-pyrrolo[2,3-b]pyridine (CAS 916177-01-0)
- (S)-tert-Butyl ((5-oxopyrrolidin-3-yl)methyl)carbamate (CAS 220226-10-8)
- 2-Amino-8-hydroxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid (CAS 168628-97-5)
- Methyl (E)-3-(2-ethynylthiazol-4-yl)acrylate (CAS 2786829-59-0)
- Methyl 1-(2,6-dichlorophenyl)-4-isopropyl-1H-1,2,3-triazole-5-carboxylate (CAS 1643862-37-6)
- Tirzepatide Impurity 35 (CAS CATO-C4X-324035)
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