Vericiguat Impurity 78 CAS CATO-C4X-289678
| CAS No. | CATO-C4X-289678 |
| Molecular Formula | C23H18FN9 |
| Molecular Weight | 439.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Vericiguat Impurity 78.
Vericiguat Impurity 78 (CAS CATO-C4X-289678) is a certified pharmaceutical impurity reference standard with the molecular formula C23H18FN9 and a molecular weight of 439.45 g/mol.
The molecular framework of Vericiguat Impurity 78 (C23H18FN9) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Vericiguat Impurity 78 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H18FN9 |
| Molecular Weight | 439.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 9 |
Related Vericiguat Standards
- Vericiguat Impurity 12 (CAS CATO-C4X-289612)
- Vericiguat Impurity 18 (CAS CATO-C4X-289618)
- Vericiguat impurity 48 (CAS CATO-C4X-289648)
- Vericiguat Impurity 21 (CAS CATO-C4X-289621)
- Vericiguat Impurity 35 (CAS CATO-C4X-289635)
- Vericiguat impurity 49 (CAS CATO-C4X-289649)
- Vericiguat impurity 54 (CAS CATO-C4X-289654)
- Vericiguat Impurity 36 (CAS CATO-C4X-289636)
Recommended Standards
- Riociguat Impurity N2 （E-isomer） (CAS 370879-49-5)
- Riociguat Impurity N40 (CAS 428854-23-3)
- Methyl 2-((3-(3-(trifluoromethyl)phenyl)quinolin-2-yl)thio)benzoate (CAS 339103-30-9)
- (4Z)-3-tert-Butyl-1-(4-nitrophenyl)-4-[(3,4,5-trimethoxyphenyl)methylidene]-4,5-dihydro-1H-pyrazol-5-one (CAS 1025878-53-8)
- Flurbiprofen Impurity 104 (CAS CATO-C4X-1444104)
- Bedaquiline Impurity 9 (CAS 791633-38-0)
- Sildenafil Impurity 28 (CAS 139756-26-6)
- 4,4''-Dichloro-5'-(1H-imidazol-1-yl)-[1,1':3',1''-terphenyl]-2'-amine (CAS 647835-45-8)
- (S)-2-Amino-3-(4-ethylphenyl)propanoicacid (CAS 4313-70-6)
- (2E)-3-(2-Chlorophenyl)-1-(2-methoxyphenyl)prop-2-en-1-one (CAS 1482338-69-1)
- Doxepin EP Imp C(Desmethyldoxepine)(USP (CAS 1225-56-5)
- (5-Methylisoxazol-3-yl)methyl methanesulfonate (CAS 783325-24-6)
- (1-((S)-2-Acetamidopropanoyl)pyrrolidin-2-yl)boronic acid (CAS 915283-74-8)
- Semaglutide impurity 73 (CAS CATO-C4X-222673)
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