Amlodipine Mesilate Monohydrate - API Standards CAS 440358-84-9
| CAS No. | 440358-84-9 |
| Molecular Formula | C20H25ClN2O5 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Amlodipine Mesilate Monohydrate - API Standards is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Amlodipine Mesilate Monohydrate - API Standards (CAS 440358-84-9), molecular formula C20H25ClN2O5CH4O3SH2O and molecular weight 522.99 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Amlodipine Mesilate Monohydrate - API Standards is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 522.99 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H25ClN2O5 CH4O3S H2O |
| Molecular Weight | 522.99 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Amlodipine Standards
- Amlodipine Impurity N32 (CAS 103094-30-0)
- (R)-Amlodipine (CAS 103129-81-3)
- Amlodipine (S)-Isomer (CAS 103129-82-4)
- Amlodipine Impurity N5 (CAS 107812-86-2)
- Amlodipine Impurity N2 (CAS 111429-90-4)
- Amlodipine Besylate (CAS 111470-99-6)
- Amlodipine Impurity N4 (CAS 113994-36-8)
- Amlodipine Impurity 38 (CAS 113994-37-9)
Recommended Standards
- 1-Methyl-1-oxo-1phosphinan-4-one (CAS 54662-09-8)
- 2-((2-Ethoxyethyl)thio)pyridine (CAS 121203-09-6)
- 2-Hydroxy-6-(2-methoxyphenyl)nicotinonitrile (CAS 128173-60-4)
- 2-Bromo-6,6-dimethyl-4,5,6,7-tetrahydrobenzofuran-7-amine (CAS 2090116-53-1)
- 4-Chloro-N-cyclohexyl-N-phenylbutanamide (CAS 1023536-91-5)
- 2-Fluoro-5-(trifluoromethyl)pyridin-3-amine (CAS 72600-65-8)
- Tert-butyl 2-hydroxy-3H-imidazo[4,5-b]pyridine-3-carboxylate (CAS 1027159-01-8)
- 2-(Isobutylamino)-2-methylpropanoic acid (CAS 1183157-21-2)
- 3-(2,4-Difluorophenyl)-2-hydroxypropanoic acid (CAS 1523285-07-5)
- Semaglutide Impurity 5 (CAS 23406-82-8)
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