Macitentan Impurity 2 CAS 441796-13-0
| CAS No. | 441796-13-0 |
| Molecular Formula | C18H18Br2N6O4S |
| Molecular Weight | 574.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Macitentan Impurity 2 (CAS 441796-13-0, C18H18Br2N6O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Macitentan Impurity 2 (C18H18Br2N6O4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 574.25 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Macitentan Impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H18Br2N6O4S |
| Molecular Weight | 574.25 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Macitentan Standards
- Macitentan Impurity 24 (CAS 556797-16-1)
- Macitentan (CAS 441798-33-0)
- Macitentan Impurity 26 (CAS CATO-C4X-117526)
- Macitentan Impurity 1 (CAS 441798-25-0)
- Macitentan-d4 (CAS 1258428-05-5)
- Macitentan Impurity 27 (CAS CATO-C4X-117527)
- Macitentan Impurity 3 (CAS 1103522-45-7)
- Macitentan Impurity 8 (CAS 556796-88-4)
Recommended Standards
- 3,3'-Diiodo-2,2'-dimethoxy-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthalene (CAS 400027-47-6)
- Fluralaner Impurity 57 (CAS 1122021-93-5)
- (1S)-5,5′,6,6′,7,7′,8,8′-Octahydro-3,3′-diiodo-2,2′-dimethoxy-1,1′-binaphthalene (CAS 1826047-44-2)
- N-(4,5-Dibromo-2-([(4-methylphenyl)sulfonyl]amino)phenyl)-4-methylbenzenesulfonamide (CAS 88617-67-8)
- Entacapone EP Impurity I (CAS 1364322-42-8)
- Cinacalcet Impurity N57 (CAS 1271930-15-4)
- Daptomycin Impurity 6 (CAS CATO-C4X-13786)
- (4-Amino-2-butylpyrimidin-5-yl)methanol (CAS 62671-93-6)
- 3-Chloro-5,6-dimethylpyrazine-2-carbonitrile (CAS 153809-15-5)
- 4-[3-(trifluoromethyl)phenyl]butanal (CAS 1343365-32-1)
- Danusertib (CAS 827318-97-8)
- 4-((4-Formylphenyl)(methyl)amino)benzonitrile (CAS 1282235-93-1)
- BEPP Monohydrochloride (CAS 455311-98-5)
- Semaglutide Impurity 1(OtBu-Ste-D-γGlu(OtBu)-AEEA-AEEA-OH) (CAS CATO-C4X-22261)
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