Macitentan Impurity 1 CAS 441798-25-0
| CAS No. | 441798-25-0 |
| Molecular Formula | C17H16Br2N6O4S |
| Molecular Weight | 560.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 560.22 g/mol gives Macitentan Impurity 1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Macitentan Impurity 1 (CAS 441798-25-0), a pharmacopoeial impurity reference standard (molecular formula C17H16Br2N6O4S, MW 560.22 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C17H16Br2N6O4S, Macitentan Impurity 1 contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 560.22 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H16Br2N6O4S |
| Molecular Weight | 560.22 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Macitentan Standards
- Macitentan Impurity 2 (CAS 441796-13-0)
- Macitentan Impurity 3 (CAS 1103522-45-7)
- Macitentan Impurity 8 (CAS 556796-88-4)
- Macitentan Impurity N1 (CAS 2443747-63-3)
- Macitentan Impurity 35 (CAS 441798-36-3)
- Macitentan Impurity 24 (CAS 556797-16-1)
- Macitentan (CAS 441798-33-0)
- Macitentan Impurity 26 (CAS CATO-C4X-117526)
Recommended Standards
- N,N'-[Bis(2,6-diMethylphenyl)-1,3-diMethyl-1,3-propanediylidene](Methyl) (triethylphosphine)palladiuM(II) (CAS 1224879-40-6)
- 1,4-Dibromo-2,5-bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzene (CAS 187754-76-3)
- Amiodarone Impurity 35 (CAS 149702-94-3)
- Methoxytris(pentafluorophenyl)silane (CAS 223668-78-8)
- Lemborexant Impurity 30 (CAS CATO-C4X-304230)
- Olaparib Impurity 102 (CAS 1806327-68-3)
- Doxofylline impurity 44 (CAS CATO-C4X-151344)
- 3-(Isoxazol-5-yl)aniline (CAS 832740-15-5)
- 3-Chloro-1H-indazole-7-carbaldehyde (CAS 1337880-07-5)
- 2-[2-(2-bromophenyl)ethylsulfanyl]acetyl chloride (CAS 2737317-24-5)
- (S)-3-(Trifluoromethyl)-5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine (CAS 2817669-24-0)
- 7-Amino-3,4-dihydro-2H-1,4-benzoxazine (CAS 575474-01-0)
- Naproxen EP Impurity M (CAS 93-04-9)
- Des-Phe22-Tirzepatide (CAS CATO-CPTD788951)
Why CATO?
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