Macitentan Impurity 3 CAS 1103522-45-7
| CAS No. | 1103522-45-7 |
| Molecular Formula | C16H14Br2N6O4S |
| Molecular Weight | 546.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 546.19 g/mol gives Macitentan Impurity 3 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Macitentan Impurity 3 (CAS 1103522-45-7, C16H14Br2N6O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution, Macitentan Impurity 3 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 546.19 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Macitentan Impurity 3 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H14Br2N6O4S |
| Molecular Weight | 546.19 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Macitentan Standards
- Macitentan Impurity 8 (CAS 556796-88-4)
- Macitentan Impurity N1 (CAS 2443747-63-3)
- Macitentan Impurity 35 (CAS 441798-36-3)
- Macitentan Impurity 1 (CAS 441798-25-0)
- Macitentan Impurity 55 (CAS CATO-C4X-117555)
- Macitentan Impurity 2 (CAS 441796-13-0)
- Macitentan Impurity 16 (CAS 2211059-00-4)
- Macitentan Impurity 56 (CAS CATO-C4X-117556)
Recommended Standards
- Atogepant Impurity 10 (CAS CATO-C4X-328510)
- Dotinurad Impurity 262 (CAS CATO-C4X-2494262)
- 1-(3,5-Bis(perfluorobutyl)-1H-pyrazol-1-yl)ethan-1-one (CAS 247170-28-1)
- tert-butyl N-(6-bromo-3-iodo-imidazo[1,2-a]pyridin-8-yl)-N-tert-butoxycarbonyl-carbamate (CAS 2698371-93-4)
- Tigecycline Impurity 4 (CAS CATO-C4X-18604)
- Azithromycin impurity 62 (CAS 857078-26-3)
- Rasagiline Impurity 31 (CAS CATO-C4X-191351)
- (R)-Beta-Dihydroergocryptine (CAS 88660-47-3)
- Decahydro-1H-benzo[b]azepine (CAS 1378369-63-1)
- 3-Phenylbutan-2-ol (CAS 52089-32-4)
- Benzyl(3,3-dimethylbutyl)amine (CAS 167693-21-2)
- Thymosin b4 (16-38) (CAS 113318-05-1)
- 3,5-Difluoro-3-(4-methoxyphenyl)propiophenone (CAS 898776-43-7)
- Semaglutide impurity 96 (CAS CATO-C4X-222696)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com