Sunitinib Impurity 45 CAS 443-69-6
| CAS No. | 443-69-6 |
| Molecular Formula | C8H4FNO2 |
| Molecular Weight | 165.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Sunitinib Impurity 45 (CAS 443-69-6) is a certified pharmaceutical impurity reference standard with the molecular formula C8H4FNO2 and a molecular weight of 165.12 g/mol.
Structurally, Sunitinib Impurity 45 (C8H4FNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 165.12 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures Sunitinib Impurity 45 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H4FNO2 |
| Molecular Weight | 165.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Sunitinib Standards
- Sunitinib Impurity 51 (CAS 253870-02-9)
- Sunitinib Impurity 3 (CAS 2199-51-1)
- Sunitinib Impurity 57 (CAS CATO-C4X-133357)
- Sunitinib Impurity 16 (CAS 56341-41-4)
- Sunitinib Impurity 46 (CAS 138343-94-9)
- Sunitinib Impurity 47 (CAS 56341-39-0)
- Sunitinib Impurity 48 (CAS 71294-03-6)
- Sunitinib Impurity 87 (CAS 1032268-12-4)
Recommended Standards
- 3-Cyano-4-fluorobenzoic acid (CAS 171050-06-9)
- Dimethyl (S)-(2-methylaziridin-1-yl)phosphonate (CAS 1800100-62-2)
- N-methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine (CAS 898539-99-6)
- (Piperidin-4-yl)phosphonic acid (CAS 216870-40-5)
- Pitavastatin Impurity 99 (CAS 176593-07-0)
- Daprodustat Impurity 30 (CAS CATO-C4X-240730)
- Epinephrine Impurity 108 (CAS CATO-C4X-1849108)
- 1,1,1-Trimethoxybutane (CAS 43083-12-1)
- 2,5-Dichloro-N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)nicotinohydrazide (CAS 680217-58-7)
- Almonertinib impurity 3 (CAS CATO-C4X-28923)
- 1-(5-(Tert-butyl)-2-hydroxyphenyl)butan-1-one (CAS 75060-53-6)
- 1-(5-Bromopyridin-3-yl)piperidine-4-carbonitrile (CAS 1289110-84-4)
- 3,6-Dibromo-1,2,4,5-tetrazine (CAS 1071030-18-6)
- Semaglutide impurity 197 (CAS CATO-C4X-2226197)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com