Vardenafil Impurity 67 CAS 448184-60-9
| CAS No. | 448184-60-9 |
| Molecular Formula | C17H21N5O4S |
| Molecular Weight | 391.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Vardenafil Impurity 67.
CATO supplies Vardenafil Impurity 67 (CAS 448184-60-9), a pharmacopoeial impurity reference standard (molecular formula C17H21N5O4S, MW 391.44 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Vardenafil Impurity 67 (C17H21N5O4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H21N5O4S |
| Molecular Weight | 391.44 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Vardenafil Standards
- Vardenafil EP Impurity B (CAS 437717-43-6)
- Vardenafil Impurity 50 (CAS CATO-C4X-101750)
- Vardenafil Impurity 60 (CAS CATO-C4X-101760)
- Vardenafil Impurity 39 (CAS 2580939-41-7)
- Vardenafil Impurity 15 (CAS CATO-C4X-101715)
- Vardenafil Impurity 53 (CAS CATO-C4X-101753)
- Vardenafil Impurity 56 (CAS CATO-C4X-101756)
- Vardenafil Impurity 59 (CAS CATO-C4X-101759)
Recommended Standards
- Argatroban Impurity 98 (CAS CATO-C4X-100798)
- Rabeprazole EP Impurity I (CAS 924663-37-6)
- Tert-butyl 2-((8,9-dimethoxy-2-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)thio)acetate (CAS 672949-29-0)
- Sildenafil Impurity 27 (CAS 372089-76-4)
- Avibactam Impurity 63 (CAS CATO-C4X-134863)
- Acalabrutinib Impurity 2 (CAS CATO-C4X-30552)
- Tryptophan EP Impurity B (Mixture of Diastereomers) (CAS 184955-21-3)
- (S)-2-Amino-2-(3-chlorophenyl)ethanol hydrochloride (CAS 620616-08-2)
- 4-(Aminomethyl)-2-methylbenzoic acid (CAS 73830-99-6)
- Benzenepropanamide, α-amino-N-[3-(1H-imidazol-1-yl)propyl]-, dihydrochloride, (αS)- (CAS 1573006-37-7)
- 3-[(Ethylsulfanyl)methyl]pyridin-2-amine (CAS 1247579-87-8)
- COF-V (CAS 2065232-77-9)
- 1-(Dimethylamino)-3-oxo-3-(tetrahydro-2H-pyran-4-yl)prop-1-en-2-yl benzoate (CAS 2415222-43-2)
- Semaglutide impurity 91 (CAS CATO-C4X-222691)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com