Acalabrutinib Impurity 2 CAS CATO-C4X-30552
| CAS No. | CATO-C4X-30552 |
| Molecular Formula | C18H18BrN5O2 |
| Molecular Weight | 416.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C18H18BrN5O2, Acalabrutinib Impurity 2 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 416.27 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Acalabrutinib Impurity 2 (CAS CATO-C4X-30552, C18H18BrN5O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Acalabrutinib Impurity 2 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H18BrN5O2 |
| Molecular Weight | 416.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 5 |
Related Acalabrutinib Standards
- Acalabrutinib Impurity 3 (CAS CATO-C4X-30553)
- Acalabrutinib Impurity 4 (CAS 2198380-46-8)
- Acalabrutinib Impurity 16 (CAS 2230757-50-1)
- Acalabrutinib Impurity 13 (CAS CATO-C4X-305513)
- Acalabrutinib Impurity 12 (CAS CATO-C4X-305512)
- Acalabrutinib Impurity 10 (CAS CATO-C4X-305510)
- Acalabrutinib Impurity 15 (CAS CATO-C4X-305515)
- Acalabrutinib Impurity 18 (CAS CATO-C4X-305518)
Recommended Standards
- Methyl 5-bromo-4-(N-methanesulfonylmethanesulfonamido)-2-methoxybenzoate (CAS 860785-04-2)
- Butyl 1-bromo-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate (CAS 808115-53-9)
- 6-Bromo-4-methyl-1-phenyl-3H-naphtho[1,2,3-de]quinoline-2,7-dione (CAS 67499-52-9)
- 109376-83-2 E2C2LB77BF ML 7 1H-1,4-Diazepine, hexahydro-1-((5-iodo-1-naphthalenyl)sulfonyl)- 1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hcl ML-7 ML7 UNII-E2C2LB77BF (CAS 109376-83-2)
- Udenafil Impurity 1 (CAS CATO-C4X-33721)
- Iopromide impurity 13 (CAS CATO-C4X-183213)
- Pomalidomide Impurity 8 (CAS 603-11-2)
- Benzenamine, 4,4'-methylenebis-, polymer with 2-methyloxirane (CAS 67786-32-7)
- (2-(Isopentyloxy)naphthalen-1-yl)boronic acid (CAS 1313760-73-4)
- Ethyl 5-methyl-3-(thiophen-2-yl)-1H-pyrrole-2-carboxylate (CAS 31894-56-1)
- (S)-2-Amino-3-(2,5-difluorophenyl)propanoic acid (CAS 31105-92-7)
- methyl 1,3-benzothiazole-6-carboxylate (CAS 73931-63-2)
- Ethyl 6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylate (CAS 533910-45-1)
- Tirzepatide Impurity 11 TFA salt (CAS CATO-C4X-324011)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com