Mometasone Furoate EP Impurity Q CAS 83881-08-7
| CAS No. | 83881-08-7 |
| Molecular Formula | C22H27ClO4 |
| Molecular Weight | 390.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Mometasone Furoate EP Impurity Q (CAS 83881-08-7, C22H27ClO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Mometasone Furoate EP Impurity Q (C22H27ClO4) contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 390.90 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H27ClO4 |
| Molecular Weight | 390.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Cl-containing |
Related Mometasone Standards
- Mometasone EP Impurity M (CAS 57780-86-6)
- Mometasone Impurity 51 (CAS CATO-C4X-170451)
- Mometasone Furoate Impurity 25 (CAS CATO-C4X-170425)
- Mometasone Impurity C13 (CAS 151265-36-0)
- Mometasone Furoate Impurity 24 (CAS CATO-C4X-170424)
- Mometasone Furoate EP Impurity K (CAS 4647-20-5)
- Mometasone Related Compound 4 (CAS 37413-91-5)
- Mometasone Impurity 28 (CAS CATO-C4X-170428)
Recommended Standards
- Hydroxyzine Impurity 5 (CAS 2469273-48-9)
- PBB No. 26 (CAS 59080-35-2)
- Beclomethasone-Δ17,20 21-Aldehyde(E/Z Mixture) (CAS 1174035-77-8&1174035-80-3)
- 2,6-Diiodo-4-nitrophenol (CAS 305-85-1)
- Clindamycin Impurity 142 (CAS CATO-C4X-1341142)
- Apixaban Impurity 149 (CAS CATO-C4X-1088149)
- Ketorolac Impurity 33 (CAS CATO-C4X-166933)
- 5-(3,4-Difluorophenyl)-1,2,4-oxadiazole-3-carboxylic acid (CAS 1340132-51-5)
- N-(3-Aminophenyl)-4-(hexyloxy)benzamide (CAS 1020722-37-5)
- 2,3,4,6-Tetra-O-acetyl-D-glucopyranose (CAS 10343-06-3)
- 4-Pentafluoroethyl-3-trifluoromethylbenzonitrile (CAS 1208078-86-7)
- 3-Methyl-1,2,3,4-tetrahydroquinoxalin-2-one (CAS 34070-68-3)
- Posaconazole Impurity 86 (CAS 170985-84-9)
- Galanin (1-13)-Neuropeptide Y (25-36) amide (CAS 147138-51-0)
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