Granisetron EP Impurity D CAS 50890-83-0
| CAS No. | 50890-83-0 |
| Molecular Formula | C9H8N2O2 |
| Molecular Weight | 176.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Granisetron EP Impurity D (CAS 50890-83-0, C9H8N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C9H8N2O2, Granisetron EP Impurity D contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 176.17 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Granisetron EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8N2O2 |
| Molecular Weight | 176.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Nitrogen Atoms | 2 |
Related Granisetron Standards
- Granisetron EP Impurity G (CAS 34252-44-3)
- Granisetron EP Impurity H (CAS 4498-67-3)
- Granisetron Impurity 12 (CAS 106649-02-9)
- Granisetron EP Impurity E (CAS 76272-56-5)
- Granisetron Impurity 10 (CAS 123704-99-4)
- Granisetron Impurity 11(Mixture of Z and E Isomers) (CAS 123704-98-3)
- Granisetron Impurity 27 (CAS 10604-20-3)
- Granisetron Impurity 24 (CAS CATO-C4X-197024)
Recommended Standards
- Zonisamide Impurity 14 (CAS 23008-68-6)
- Rizatriptan Impurity 13 (CAS 91192-27-7)
- Ozagrel Impurity 26 （predominantly trans） (CAS 23359-08-2)
- Levodopa Impurity 13 (CAS 1176784-51-2)
- Empagliflozin Impurity 291 (CAS CATO-C4X-1065291)
- Olmesartan impurity 98 (CAS CATO-C4X-109798)
- Baclofen Impurity 67 (CAS CATO-C4X-101267)
- 5-Chloro-3-ethyl-1,2,4-oxadiazole (CAS 1250086-72-6)
- (2S,4S,5S)-1-(3,5-Di-tert-butylphenyl)-3-(2-methylnaphthalen-1-yl)-4,5-diphenyl-1,3,2-diazaphospholidine 2-oxide (CAS 2851432-36-3)
- 2,6-Dichloro-3-iodopyridin-4-amine (CAS 1235873-11-6)
- N-(2-aminoethyl)-4-nitrobenzene-1-sulfonamide hydrochloride (CAS 1209994-16-0)
- 7'-Nitrospiro[cyclopropane-1,3'-indoline]-2'-one (CAS 83414-08-8)
- Denibulin (CAS 284019-34-7)
- Liraglutide(3-31)TFA Salt (CAS CATO-C4X-19921)
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