Rebamipide impurity 21 CAS 452322-61-1
| CAS No. | 452322-61-1 |
| Molecular Formula | C22H20ClNO4 |
| Molecular Weight | 397.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Rebamipide impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Rebamipide impurity 21 (CAS 452322-61-1), a pharmacopoeial impurity reference standard (molecular formula C22H20ClNO4, MW 397.85 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Rebamipide impurity 21 (C22H20ClNO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 397.85 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H20ClNO4 |
| Molecular Weight | 397.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Rebamipide Standards
- Rebamipide impurity 28 (CAS CATO-C4X-152328)
- Rebamipide impurity 15 (CAS CATO-C4X-152315)
- Rebamipide Impurity 52 (CAS CATO-C4X-152352)
- Rebamipide Impurity 29 (CAS CATO-C4X-152329)
- Rebamipide Impurity 7 (CAS 90098-08-1)
- Rebamipide impurity 18 (CAS CATO-C4X-152318)
- Rebamipide Impurity 6 (CAS 90098-38-7)
- Rebamipide-d4 (CAS 1219409-06-9)
Recommended Standards
- Erlotinib Impurity 2 (CAS 183321-85-9)
- 1-(3-Chlorophenyl)-3-(1-(3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl)cyclohexyl)urea (CAS 1396856-26-0)
- Prucalopride Impurity 40（DP-3） (CAS 1900715-94-7)
- 2-(2-Chlorophenyl)-N-{1-[3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl]cyclohexyl}acetamide (CAS 1396860-62-0)
- Buspirone Impurity 42 (CAS CATO-C4X-125842)
- Venetoclax Impurity 46 (CAS CATO-C4X-249546)
- CAS 109964-71-8 (CAS 109964-71-8)
- Fmoc-(R)-3-amino-4-(2-cyano-phenyl)-butyric acid (CAS 269726-81-0)
- 2-Bromo-3-chloro-5-fluorotoluene (CAS 1242339-16-7)
- 3-Chloroisonicotinaldehyde hydrochloride (CAS 1826110-00-2)
- N-(2-(piperazin-1-yl)ethyl)ethanesulfonamide hydrochloride (CAS 1583199-15-8)
- 7-Bromo-3-phenylbenzofuran (CAS 42434-89-9)
- 3-(3-Pyrazin-2-yl-1,2,4-oxadiazol-5-yl)propanoic acid (CAS 849925-05-9)
- D-Ser32-Tirzepatide (CAS CATO-CPTD788692)
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