4-(Trifluoromethyl)Benzaldehyde CAS 455-19-6
| CAS No. | 455-19-6 |
| Molecular Formula | C8H5F3O |
| Molecular Weight | 174.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(Trifluoromethyl)Benzaldehyde.
4-(Trifluoromethyl)Benzaldehyde (CAS 455-19-6) is a high-purity analytical reference standard with the molecular formula C8H5F3O and a molecular weight of 174.12 g/mol.
The molecular framework of 4-(Trifluoromethyl)Benzaldehyde (C8H5F3O) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5F3O |
| Molecular Weight | 174.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Trifluoromethyl Standards
- 2-(Trifluoromethyl)-5-vinylpyrimidine (CAS 1147938-06-4)
- 2-[(trifluoromethyl)sulfanyl]propanoic acid (CAS 63471-78-3)
- 3-[(trifluoromethyl)thio]propanoic acid (CAS 29271-33-8)
- Methyl 2-((trifluoromethyl)thio)acetate (CAS 80783-58-0)
- 1-Ethyl-2-(trifluoromethyl)benzene (CAS 74423-01-1)
- 1-Ethyl-3-(trifluoromethyl)benzene (CAS 27190-70-1)
- 1-Ethyl-4-(trifluoromethyl)benzene (CAS 27190-69-8)
- 2-(trifluoromethyl)-1,3-oxathiolan-2-amine (CAS 70247-64-2)
Recommended Standards
- Cinacalcet Impurity 49 (CAS 447-61-0)
- 2',4',5'-Trifluoroacetophenone (CAS 129322-83-4)
- Cinacalcet Impurity 35 (CAS 454-89-7)
- 4-Fluoro-5-methoxy-1-methyl-1H-pyrazole-3-carboxylic acid (CAS 1774891-89-2)
- 4-methyl-4H-1,2,4-triazole-3-sulfonic acid (CAS 29982-43-2)
- 1,1-Dimethylethyl 1,4-dihydro-6,7-dimethylnaphthalen-1,4-imine-9-carboxylate (CAS 885691-68-9)
- 2-Fluoro-4-(2-tetrahydropyranyloxy)benzeneboronic acid pinacol ester, 97% (CAS 1449145-06-5)
- 2-(3-Amino-4-chloro-1h-pyrazol-1-yl)-N-carbamoylacetamide (CAS 1342491-00-2)
- Lithium 6,7-dihydro-4H-pyrano[4,3-d]thiazole-2-carboxylate (CAS 259810-15-6)
- Dalfampridine Related Compound B (50 mg) (3,5-Dibromopyridin-4-amine) (CAS 84539-34-4)
- 2-Cyclohexyl-3-(9h-fluoren-12-ylmethoxycarbonylamino)propanoic acid (CAS 1217747-47-1)
- N-Benzyl-4-bromo-3-fluorobenzamide (CAS 1282306-68-6)
- Ethyl 4-hydroxy-2-oxo-1-phenyl-1,2-dihydro-1,8-naphthyridine-3-carboxylate (CAS 138305-20-1)
- TAT 14 Peptide (Nrf2 Activator III) (CAS 1362661-34-4)
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