Topiramate Impurity 36 CAS 455899-78-2
| CAS No. | 455899-78-2 |
| Molecular Formula | C12H20O9S |
| Molecular Weight | 340.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, Topiramate Impurity 36 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 340.35 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Topiramate Impurity 36 (CAS 455899-78-2, C12H20O9S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H20O9S |
| Molecular Weight | 340.35 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Sulfur Atoms | 1 |
Related Topiramate Standards
- Topiramate (CAS 97240-79-4)
- Topiramate Impurity 35 (CAS CATO-C4X-176835)
- Topiramate-<SUP>13</SUP>C<SUB>6</SUB> (CAS 1217455-55-4)
- Topiramate-d12 (CAS 1279037-95-4)
- Topiramate Impurity 17 (CAS 97240-80-7)
- Topiramate Impurity 27 (CAS 120238-48-4)
- Topiramate Impurity 30 (CAS CATO-C4X-176830)
- Topiramate Chlorosulfonyl Impurity (CAS 150609-95-3)
Recommended Standards
- Linezolid impurity 103 (CAS CATO-C4X-1073103)
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- Ethyl 3-((4-chlorophenyl)amino)-3-oxopropanoate (CAS 15386-84-2)
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- 2-(1-Methyl-1h-imidazol-2-yl)-1-phenylethan-1-amine (CAS 149928-42-7)
- Cefuroxime Impurity 51 (CAS 213912-35-7)
- (3-((Dimethylamino)methyl)-5-fluorophenyl)boronic acid (CAS 1672660-86-4)
- 2-(3,4,5-Trimethyl-1H-pyrazol-1-yl)ethanol (CAS 127223-53-4)
- Peptide Impurity 70 TFA Salt (CAS CATO-CPTD788570)
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