Dapagliflozin Impurity 18 CAS 461432-22-4
| CAS No. | 461432-22-4 |
| Molecular Formula | C15H12BrClO2 |
| Molecular Weight | 339.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Dapagliflozin Impurity 18.
CATO supplies Dapagliflozin Impurity 18 (CAS 461432-22-4), a pharmacopoeial impurity reference standard (molecular formula C15H12BrClO2, MW 339.61 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine/bromine substitution, a polycyclic aromatic system, Dapagliflozin Impurity 18 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 339.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Dapagliflozin Impurity 18 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H12BrClO2 |
| Molecular Weight | 339.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl/Br-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity N51 (CAS 1404477-10-6)
- Dapagliflozin Impurity 163 (CAS CATO-C4X-1138163)
- Dapagliflozin Impurity 58 (CAS 1280647-32-6)
- Dapagliflozin Impurity 132 (CAS CATO-C4X-1138132)
- Dapagliflozin Impurity 113 (CAS CATO-C4X-1138113)
- Dapagliflozin Impurity 199 (CAS CATO-C4X-1138199)
- Dapagliflozin Impurity 10 (CAS 461432-23-5)
- Dapagliflozin Impurity 121 (CAS CATO-C4X-1138121)
Recommended Standards
- Benzyl 3-bromo-4-chloro-5-methylbenzoate (CAS 2364585-21-5)
- 6-Bromo-8-(chloromethyl)-2-phenyl-4h-benzo[d][1,3]dioxine (CAS 730950-04-6)
- 3-Bromo-5-((4-chlorophenyl)sulfonyl)-1,2,4-thiadiazole (CAS 1000574-66-2)
- 2-(3-Bromophenyl)-3-(4-chlorophenyl)propanoic acid (CAS 941280-51-9)
- (1S,2S,3R,4R)-Peramivir Impurity 95 (CAS 229615-05-8)
- Opicapone Impurity 50 (CAS CATO-C4X-240450)
- Fudosteine Impurity 85 (CAS CATO-C4X-144785)
- Methyl 2-hydroxy-5-(pyrrolidine-1-sulfonyl)benzoate (CAS 893778-49-9)
- 7-fluoro-1,2,3,4-tetrahydroisoquinoline-8-carboxylic acid hydrochloride (CAS 1989671-78-4)
- N-ε-Aminocaproyl-β-D-galactopyranosylamine (CAS 38822-56-9)
- 3-(4-(Benzyloxy)benzylidene)piperidinehydrochloride (CAS 1177426-05-9)
- (1S)-1-[2-(Trifluoromethyl)phenyl]propan-1-ol (CAS 1114384-60-9)
- 6-N-Ethylquinoline-5,6-diamine (CAS 1157504-04-5)
- Semaglutide impurity 95 (CAS CATO-C4X-222695)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com