Ketoconazole Impurity 9 CAS 331949-30-5
| CAS No. | 331949-30-5 |
| Molecular Formula | C18H15BrCl2O4 |
| Molecular Weight | 446.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Ketoconazole Impurity 9 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Ketoconazole Impurity 9 (CAS 331949-30-5, C18H15BrCl2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C18H15BrCl2O4, Ketoconazole Impurity 9 contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 446.12 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C18H15BrCl2O4 |
| Molecular Weight | 446.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl/Br-containing |
Related Ketoconazole Standards
- Ketoconazole impurity 34 (CAS CATO-C4X-147234)
- Ketoconazole Impurity 36 (CAS CATO-C4X-147236)
- Ketoconazole Impurity 6 (CAS 61397-56-6)
- Ketoconazole Impurity 10 (CAS 70894-66-5)
- Ketoconazole impurity 30 (CAS CATO-C4X-147230)
- Ketoconazole EP Impurity E (CAS 134071-44-6)
- Ketoconazole Impurity 14 (CAS 170210-50-1)
- Ketoconazole impurity 32 (CAS CATO-C4X-147232)
Recommended Standards
- Perfluoro(4-methyl-3,6-dioxaoct-7-ene)sulfonyl Fluoride (CAS 16090-14-5)
- (7-Bromo-6-(bromomethyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)methyl pivalate (CAS 140395-66-0)
- 3-(2,4-Dichlorobenzoyl)-5-(3,4-dichlorobenzylidene)-2-thioxoimidazolidin-4-one (CAS 732288-03-8)
- trans-[2-Bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl Benzoate (CAS 61397-57-7)
- Leflunomide Impurity 15 (CAS 4637-24-5)
- Nilotinib Impurity 16 (CAS 641571-13-3)
- Flurbiprofen Impurity 17 (CAS 78543-08-5)
- 2,4,5,6-Tetrachloroquinazoline (CAS 78052-21-8)
- [2-(4-Ethoxyphenyl)-5-methyl-1,3-oxazol-4-yl]methanol (CAS 1031630-25-7)
- 1-(4-Fluorobenzoyl)cyclopropan-1-amine (CAS 1017487-17-0)
- 2-Amino-5-methoxypyridine (CAS 10167-97-2)
- (S)-N-Boc-2-[4-(benzyloxy)phenyl]-1-[(S)-oxiran-2-yl]ethylamine (CAS 162536-84-7)
- n-(1-(2-Methoxyphenyl)ethyl)butan-2-amine (CAS 1019605-04-9)
- FMRF Amide Related Peptide. (CAS 149471-12-5)
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