Dutasteride Impurity 21 CAS 4640-41-9
| CAS No. | 4640-41-9 |
| Molecular Formula | C8H2Cl2N2O2 |
| Molecular Weight | 229.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Dutasteride Impurity 21 (C8H2Cl2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Dutasteride Impurity 21 (CAS 4640-41-9, C8H2Cl2N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Dutasteride Impurity 21 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H2Cl2N2O2 |
| Molecular Weight | 229.02 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Dutasteride Standards
- Dutasteride Impurity 19 (CAS 313-13-3)
- Dutasteride Impurity 20 (CAS 3822-20-6)
- Dutasteride Impurity 21 (CAS 2965-07-3)
- Dutasteride Impurity 4 (CAS 328-93-8)
- Dutasteride Impurity 15 (CAS 84-58-2)
- Dutasteride impurity G (CAS 433-19-2)
- Dutasteride Impurity 22 (CAS 320-88-7)
- Dutasteride Impurity 22 (CAS 55982-15-5)
Recommended Standards
- 5-Bromofuran-2-sulfonyl fluoride (CAS 2137682-74-5)
- 5-(5-Bromo-2-furyl)-1H-1,2,4-triazol-3-amine (CAS 1016534-75-0)
- 4-Ethynyl-3-iodopyridine (CAS 860021-80-3)
- 2,4-Dichloro-1-(2,2,2-trifluoroethyl) benzene 2,4-dichloro-1-(2,2,2-trifluoroethyl)-benzene 1092350-09-8 (CAS 1092350-09-8)
- Dronedarone Impurity 75 (CAS 2003093-69-2)
- Budesonide EP Impurity D (Mixture of Epimer) (CAS 85234-63-5)
- Roxadustat Impurity 66 (CAS 2222121-34-6)
- Trihexyl(tetradecyl)phosphonium bis(2-ethylhexyl) phosphate (CAS 1092655-30-5)
- Palladium, dichlorobis(4-methyl-2-pyridinamine-N1)- (CAS 77839-67-9)
- 8-Bromochroman-3-ol (CAS 133118-79-3)
- 5-Amino-1-methyl-1H-imidazole-4-carbimidoyl cyanide (CAS 765943-20-2)
- 4,6-Diamino-1-methyl-1,3,5-triazin-2(1H)-one (CAS 127480-12-0)
- Ipratropium Bromide EP Impurity C (CAS 552-63-6)
- Semaglutide impurity 101 (CAS CATO-C4X-2226101)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com