Orforglipron impurity 33 CAS CATO-C4X-323433
| CAS No. | CATO-C4X-323433 |
| Molecular Formula | C8H6BrFN2 |
| Molecular Weight | 229.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Orforglipron impurity 33.
As a process- or degradation-related impurity, Orforglipron impurity 33 (CAS CATO-C4X-323433, C8H6BrFN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C8H6BrFN2, Orforglipron impurity 33 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 229.05 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Orforglipron impurity 33 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6BrFN2 |
| Molecular Weight | 229.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Orforglipron Standards
- Orforglipron impurity 127 (CAS 2203400-61-5)
- Orforglipron impurity 22 (CAS 3047293-07-9)
- Orforglipron Impurity 40 (CAS CATO-C4X-323440)
- Orforglipron Impurity 53 (CAS CATO-C4X-323453)
- Orforglipron impurity 35 (CAS 7254-19-5)
- Orforglipron impurity 140 (CAS 757247-91-9)
- Orforglipron impurity 27 (CAS 465529-57-1)
- Orforglipron impurity 136 (CAS 2274775-42-5)
Recommended Standards
- 8-Bromo-5-fluoro-2H-chromene (CAS 457628-52-3)
- 3,5-Dichloro-N-(cyanomethyl)benzamide (CAS 100479-58-1)
- 7-Bromo-5-fluoro-2-methyl-2H-indazole (CAS 2090433-95-5)
- 2,3-Dichloro-2,3-dihydronaphthalene-1,4-dione (CAS 1013-00-9)
- Dabrafenib Impurity 30 (CAS CATO-C4X-303330)
- Atracurium Impurity 30 (CAS 64228-78-0)
- Indometacin Impurity 41 (CAS CATO-C4X-147041)
- 2-((4-Chloro-6-((4-sulfophenyl)amino)-1,3,5-triazin-2-yl)(octyl)amino)acetic acid (CAS 54015-15-5)
- Berotralstat (CAS 1809010-50-1)
- 6-Chloro-2-(methylthio)oxazolo[5,4-b]pyridine (CAS 1206716-60-0)
- 5,7-Dimethyl-3-[(2-m-tolyl-ethylamino)-methyl]-1H-quinolin-2-one (CAS 917562-13-1)
- 1,3,5,2,4,6-Trioxatriphosphorinane, 2,4,6-tributyl-, 2,4,6-trioxide(50% in EA) (CAS 163755-62-2)
- n-(2,3-Dimethylphenyl)-3,5-dimethylisoxazole-4-carboxamide (CAS 357326-67-1)
- Calcitonin N-Terminal Flanking Peptide (human) (CAS 118277-01-3)
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