3-(4-Chlorophenyl)-N-(3,4-dichlorophenyl)-5-(methylsulfanyl)thiophene-2-carboxamide CAS 477858-04-1
| CAS No. | 477858-04-1 |
| Molecular Formula | C18H12Cl3NOS2 |
| Molecular Weight | 428.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(4-Chlorophenyl)-N-(3,4-dichlorophenyl)-5-(methylsulfanyl)thiophene-2-carboxamide.
3-(4-Chlorophenyl)-N-(3,4-dichlorophenyl)-5-(methylsulfanyl)thiophene-2-carboxamide (CAS 477858-04-1), molecular formula C18H12Cl3NOS2 and molecular weight 428.78 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 3-(4-Chlorophenyl)-N-(3,4-dichlorophenyl)-5-(methylsulfanyl)thiophene-2-carboxamide (C18H12Cl3NOS2) contains a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 428.78 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3-(4-Chlorophenyl)-N-(3,4-dichlorophenyl)-5-(methylsulfanyl)thiophene-2-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H12Cl3NOS2 |
| Molecular Weight | 428.78 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Chlorophenyl Standards
- N-(4-chlorophenyl)-3-((2,4-dichlorobenzyl)thio)thiophene-2-carboxamide (CAS 251097-46-8)
- N-(4-chlorophenyl)-3-((3,4-dichlorobenzyl)thio)thiophene-2-carboxamide (CAS 250714-58-0)
- N-(4-Chlorophenyl)-3-{[(2,6-dichlorophenyl)methyl]sulfanyl}thiophene-2-carboxamide (CAS 251096-91-0)
- 2-[(4-Chlorophenyl)methyl]-N-[(2,4-dichlorophenyl)methyl]quinazolin-4-amine (CAS 303149-83-9)
- 2-[(4-Chlorophenyl)methyl]-N-[(3,4-dichlorophenyl)methyl]quinazolin-4-amine (CAS 303149-57-7)
- 4-(4-Chlorophenyl)-6-(3,4-dichlorophenyl)-2-(pyrrolidin-1-yl)pyridine-3-carbonitrile (CAS 303984-53-4)
- 4-(3-(2-Chlorophenyl)-1,2,4-oxadiazol-5-yl)-2-(3,4-dimethylphenyl)phthalazin-1(2H)-one (CAS 478045-66-8)
- 4-(3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl)-2-(3,4-dimethylphenyl)phthalazin-1(2H)-one (CAS 478045-68-0)
Recommended Standards
- 2-Chloroinosine 3’,4’,6’-Triacetate (CAS 41623-86-3)
- [4-(4-Chlorophenoxy)-3-nitrophenyl]methyl 4-nitrobenzoate (CAS 338960-80-8)
- (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(6-chloro-2-oxo-1H-purin-9(2H)-yl)tetrahydrofuran-3,4-diyl diacetate (CAS 161923-50-8)
- 3-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)-2-chloro-5-iodopyridin-4-amine (CAS 2883421-69-8)
- 3-(4,5-Dimethyl-4H-1,2,4-triazol-3-yl)piperidine (CAS 1250411-70-1)
- 4-(4-Bromo-1h-pyrazol-1-yl)benzenesulfonyl chloride (CAS 1174064-62-0)
- 4-(Aminomethyl)-2-chloro-6-methoxyphenol (CAS 887582-40-3)
- 4-((3,4-Dimethylphenoxy)methyl)benzohydrazide (CAS 444075-44-9)
- 2-Hydrazinyl-3,5-dinitrobenzohydrazide (CAS 1432436-41-3)
- (R)-2-(3-Chloro-5-fluorophenyl)piperidine (CAS 1213654-51-3)
- tert-butyl 2-(aminomethyl)-2-(trifluoromethyl)pyrrolidine-1-carboxylate (CAS 1893669-47-0)
- 4,4',4'',4''',4'''',4'''''-(((9,10-Dihydro-9,10-[1,2]benzenoanthracene-2,3,6,7,14,15-hexayl)hexakis(benzene-4,1-diyl))hexakis(ethyne-2,1-diyl))hexabenzoicacid (CAS 2365379-87-7)
- Aniline Hydrogen Phthalate (CAS 50930-79-5)
- Allo-D-Ile17-Tirzepatide (CAS CATO-CPTD788962)
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