4-(7-Chloro-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-yl)benzonitrile CAS 477864-79-2
| CAS No. | 477864-79-2 |
| Molecular Formula | C15H8ClN3O2 |
| Molecular Weight | 297.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-(7-Chloro-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-yl)benzonitrile is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-(7-Chloro-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-yl)benzonitrile (CAS 477864-79-2), a certified reference material (molecular formula C15H8ClN3O2, MW 297.70 g/mol) for analytical method development and quality control.
4-(7-Chloro-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-yl)benzonitrile (C15H8ClN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(7-Chloro-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-yl)benzonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H8ClN3O2 |
| Molecular Weight | 297.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 5-(2-CHloro-5-(trifluoromethyl)phenyl)isoindoline (CAS 1206970-34-4)
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- 2-Chloro-9-methyl-6-morpholino-9H-purine-8-carboxylic acid (CAS 1439824-88-0)
- 2-(4-Chloro-1H-indazol-3-yl)isoindoline-1,3-dione (CAS 88805-82-7)
- 5-Chloro-3-(3-nitrophenyl)-1H-indole-2-carbonitrile (CAS 62039-79-6)
- 7-Chloro-5-(4-methylpiperazin-1-yl)-4-nitrobenzo[c][1,2,5]oxadiazole (CAS 714919-40-1)
- 338412-61-6 4-(6-chloro-3-hydroxy-4-oxo-3,4-dihydro-2-quinazolinyl)benzenecarbonitrile KS-000035XL (CAS 338412-61-6)
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Recommended Standards
- 439112-26-2 7-(4-chlorophenyl)-6-(1H-1,2,4-triazol-1-yl)[1,2,4]triazolo[1,5-a]pyrimidine KS-00003F26 (CAS 439112-26-2)
- Nimodipine Impurity 49 (CAS CATO-C4X-138549)
- 3'-Nitro-[1,1'-biphenyl]-4-sulfonyl chloride (CAS 101366-50-1)
- Nimodipine Impurity N1 (CAS 62760-10-5)
- 3-(Bromomethyl)-1,2,4-oxadiazole (CAS 540524-13-8)
- 2,2,3,3,3-Pentafluoro-1-(4-methoxy-2-methylphenyl)propan-1-one (CAS 1443313-19-6)
- tert-butyl 4-isopropoxybenzoate (CAS 1015776-08-5)
- 3-[3-(4-Morpholinyl)propoxy]benzaldehyde (CAS 82625-44-3)
- Tolvaptan Impurity 8 (CAS 1432725-24-0)
- Rhodium(I) acetate (CAS 123798-06-1)
- Acemetacin EP Impurity E (CAS 75302-98-6)
- Topiramate Impurity 15 (CAS 128316-82-5)
- Rimegepant-d4 (CAS CATO-C4X-2487114)
- Insulin Degludec Impurity 3 (CAS CATO-C4X-21573)
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