Acemetacin EP Impurity E CAS 75302-98-6
| CAS No. | 75302-98-6 |
| Molecular Formula | C25H26ClNO6 |
| Molecular Weight | 471.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Acemetacin EP Impurity E (CAS 75302-98-6), a pharmacopoeial impurity reference standard (molecular formula C25H26ClNO6, MW 471.93 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Acemetacin EP Impurity E (C25H26ClNO6) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Acemetacin EP Impurity E under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C25H26ClNO6 |
| Molecular Weight | 471.93 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Acemetacin Standards
- Acemetacin EP Impurity D (CAS 76812-64-1)
- Acemetacin EP Impurity F (CAS 76812-49-2)
- Acemetacin EP Impurity C (CAS CATO-C4X-33821)
- Acemetacin-D4 (CAS 1196151-16-2)
- Acemetacin (CAS 53164-05-9)
- Acemetacin acyl-β-D-glucuronide (CAS 1260603-31-3)
- Acemetacin Impurity 1 (CAS 77914-62-6)
- Acemetacin EP Impurity B Potassium Salt (CAS 28751-45-3)
Recommended Standards
- 4-(Benzo[d]thiazol-2-ylthio)-3-nitrobenzyl (3-chlorophenyl)carbamate (CAS 338393-84-3)
- 2-(((4-(3,4,5-Tribromo-1H-pyrazol-1-yl)phenyl)amino)methylene)malononitrile (CAS 219793-56-3)
- 2-((4-(4-Chlorophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(naphthalen-1-yl)acetamide (CAS 586991-76-6)
- 1-(5-Chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)-3-(2-methyl-7-morpholinothiazolo[5,4-b]pyridin-6-yl)urea (CAS 2178989-63-2)
- Terazosin EP Impurity M (CAS 31350-27-3)
- Bumetanide Impurity 18 (CAS CATO-C4X-198618)
- Zanamivir EP Impurity C (CAS 130525-62-1)
- Cyproheptadine impurity 13 (CAS CATO-C4X-150613)
- 6-Cyano-4-(difluoromethyl)-5-iodopyridine-3-sulfonamide (CAS 1805375-28-3)
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- 6-Bromo-3,4-dihydrospiro[benzo[b][1,4]oxazine-2,1'-cyclopropane] (CAS 1291094-46-6)
- 1-Benzyl-3-((methoxycarbonyl)amino)-4-methylpyridin-1-ium bromide (CAS 923036-27-5)
- 5-Chloro-N-(5-chloropyridin-2-yl)-2-fluorobenzamide (CAS 1100018-31-2)
- Amyloid Precursor Frameshift Mutant C-Terminal Peptide trifluoroacetate salt (CAS 189125-14-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com