Tolvaptan Impurity 8 CAS 1432725-24-0
| CAS No. | 1432725-24-0 |
| Molecular Formula | C18H19ClN2O2 |
| Molecular Weight | 330.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Tolvaptan Impurity 8 (CAS 1432725-24-0), a pharmacopoeial impurity reference standard (molecular formula C18H19ClN2O2, MW 330.81 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Tolvaptan Impurity 8 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 330.81 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Tolvaptan Impurity 8 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H19ClN2O2 |
| Molecular Weight | 330.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tolvaptan Standards
- Tolvaptan Impurity 11 (CAS 137977-97-0)
- Tolvaptan Impurity 48 (CAS 897-82-5)
- Tolvaptan Impurity 121 (CAS CATO-C4X-1955121)
- Tolvaptan Impurity 122 (CAS CATO-C4X-1955122)
- Tolvaptan Impurity 1 (CAS 247237-38-3)
- Tolvaptan impurity 113 (CAS CATO-C4X-1955113)
- Tolvaptan Impurity 70 (CAS CATO-C4X-195570)
- Tolvaptan Impurity 92 (CAS 1580889-22-0)
Recommended Standards
- N-[6-Amino-1,2,3,4-tetrahydro-1-(2-methylpropyl)-2,4-dioxo-5-pyrimidinyl]-N-butyl-2-chloroacetamide (CAS 561009-03-8)
- Halofenozide (CAS 112226-61-6)
- N-[6-Amino-1,2,3,4-tetrahydro-1-(2-methylpropyl)-2,4-dioxo-5-pyrimidinyl]-2-chloro-N-(2-methylpropyl)acetamide (CAS 565180-48-5)
- Cyazofamid-d6 (CAS 1794756-25-4)
- Gadobutrol Impurity 186 (CAS CATO-C4X-2120186)
- Atracurium Impurity 22 (CAS CATO-C4X-185022)
- Brivaracetam Impurity 191 (CAS CATO-C4X-2007191)
- 5-Bromo-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione (CAS 2740657-28-5)
- 3-(4-Hydroxyphenyl)-1,2,4-oxadiazol-5-ol (CAS 1342289-56-8)
- (2S,4R)-4-Hydroxy-2-(hydroxymethyl)-1-pyrrolidinecarboxylic Acid tert-Butyl Ester (CAS 61478-26-0)
- tert-Butyl (4-(3-methylpyridin-2-yl)-4-oxobutyl)carbamate (CAS 1355175-73-3)
- (3-(3-(4-Ethylpiperazin-1-yl)propoxy)-4-methylphenyl)boronic acid (CAS 1704064-34-5)
- Capsaicin Impurity 3 (CAS 61229-06-9)
- Pancreatic Polypeptide (rat) (CAS 90419-12-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com