N-(3,4-dichlorobenzyl)-2-(4-(4-(pyridin-2-yl)pyrimidin-2-yl)phenoxy)acetamide CAS 478039-89-3
| CAS No. | 478039-89-3 |
| Molecular Formula | C24H18Cl2N4O2 |
| Molecular Weight | 465.33 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of N-(3,4-dichlorobenzyl)-2-(4-(4-(pyridin-2-yl)pyrimidin-2-yl)phenoxy)acetamide is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies N-(3,4-dichlorobenzyl)-2-(4-(4-(pyridin-2-yl)pyrimidin-2-yl)phenoxy)acetamide (CAS 478039-89-3), a certified reference material (molecular formula C24H18Cl2N4O2, MW 465.33 g/mol) for analytical method development and quality control.
The molecular framework of N-(3,4-dichlorobenzyl)-2-(4-(4-(pyridin-2-yl)pyrimidin-2-yl)phenoxy)acetamide (C24H18Cl2N4O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H18Cl2N4O2 |
| Molecular Weight | 465.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related N Standards
- (E)-1-(4-((2,4-dichlorobenzyl)oxy)phenyl)-3-((3,4-dichlorophenyl)amino)prop-2-en-1-one (CAS 478033-93-1)
- (E)-3-((2,4-dichlorobenzyl)oxy)-N'-(3-(trifluoromethyl)benzylidene)benzohydrazide (CAS 478032-62-1)
- 1-(2,4-Dichlorobenzyl)-N-((4-methoxyphenyl)sulfonyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (CAS 860787-54-8)
- (2-((2,6-Dichlorobenzyl)thio)-1-methyl-1H-imidazol-5-yl)methyl (4-nitrophenyl)carbamate (CAS 338422-46-1)
- 1-(2,4-Dichlorobenzyl)-2-oxo-N-(3,4,5-trimethoxyphenyl)-1,2-dihydropyridine-3-carboxamide (CAS 320419-81-6)
- 4-((2,6-Dichlorobenzyl)oxy)-2-(3-(trifluoromethyl)benzyl)quinazoline (CAS 861208-35-7)
- 3-((3,4-Dichlorobenzyl)thio)-N-(3,4-dichlorophenyl)thiophene-2-carboxamide (CAS 251096-88-5)
- 3-((3,4-Dichlorobenzyl)thio)-N-(3,5-dichlorophenyl)thiophene-2-carboxamide (CAS 251096-87-4)
Recommended Standards
- 5-(2-(Benzyloxy)phenyl)-N'-(2,4-dichlorobenzylidene)-1H-pyrazole-3-carbohydrazide (CAS 634895-31-1)
- N'-[(1E)-(2,4-Dichlorophenyl)methylidene]-3-(3,4-dimethylphenyl)-4-oxo-3,4-dihydrophthalazine-1-carbohydrazide (CAS 478045-77-1)
- 2-(2-Iodo-6-methoxyquinolin-3-yl)-5,7-dimethyl-1,3-diazaadamantan-6-ol (CAS 1442541-63-0)
- Neratinib Impurity 59 (CAS CATO-C4X-113459)
- Potassium (1-(tert-butoxycarbonyl)piperidin-3-yl)trifluoroborate (CAS 2652037-40-4)
- 3-(Bromomethyl)-1,2-benzisoxazole (CAS 37924-85-9)
- (S)-2,2',2'',2'''-(2-(4-Aminobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (CAS 181065-46-3)
- 1-(4-Acetyl-3-ethyl-5-methyl-2-pyrrolyl)-2-chloroethanone (CAS 1211362-38-7)
- 4-(2-Methyl-4-nitrophenoxy)piperidine hydrochloride (CAS 138227-67-5)
- Desonide Impurity 16 (CAS CATO-C4X-130116)
- tert-Butyl ((2S,3S)-3-hydroxybutan-2-yl)carbamate (CAS 157394-45-1)
- Ethyl 2-fluoro-3-phenylacrylate (CAS 350-99-2)
- 5-oxa-3,9,10-triazatricyclo[7.3.0.0²,⁶]dodeca-1(12),2(6),3,7,10-pentaene (CAS 2921559-90-0)
- Semaglutide Impurity 5 (CAS 23406-82-8)
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