Neratinib Impurity 59 CAS CATO-C4X-113459
| CAS No. | CATO-C4X-113459 |
| Molecular Formula | C24H18Cl2N4O2 |
| Molecular Weight | 465.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Neratinib Impurity 59 (C24H18Cl2N4O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 17.0, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 465.33 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Neratinib Impurity 59 (CAS CATO-C4X-113459, C24H18Cl2N4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Neratinib Impurity 59 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H18Cl2N4O2 |
| Molecular Weight | 465.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Neratinib Standards
- Neratinib Impurity 20 (CAS CATO-C4X-113420)
- Neratinib Impurity 2 (CAS 1144516-20-0)
- Neratinib Impurity 31 (CAS CATO-C4X-113431)
- Neratinib Impurity N1 (CAS 848139-78-6)
- Neratinib Impurity N2 (CAS 915941-95-6)
- Neratinib Impurity 62 (CAS CATO-C4X-113462)
- Neratinib Impurity 14 (CAS 1144516-14-2)
- Neratinib Impurity 10 (CAS 1144516-13-1)
Recommended Standards
- N'-[(1E)-(2,4-Dichlorophenyl)methylidene]-3-(3,4-dimethylphenyl)-4-oxo-3,4-dihydrophthalazine-1-carbohydrazide (CAS 478045-77-1)
- 2-(4-Bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid (CAS 432001-69-9)
- N-(3,4-dichlorobenzyl)-2-(4-(4-(pyridin-2-yl)pyrimidin-2-yl)phenoxy)acetamide (CAS 478039-89-3)
- 3-Bromo-4-ethoxy-N-(2-methyl-5-(6-methylbenzo[d]oxazol-2-yl)phenyl)benzamide (CAS 590397-47-0)
- Baclofen Impurity 5 (CAS 1053068-98-6)
- Atomoxetine EP Impurity H (S-Isomer) (CAS 114133-37-8)
- Nicorandil Impurity 47 (CAS 13362-26-0)
- 3,6-Dimethylheptan-2-ol (CAS 1247790-47-1)
- 3-(Furan-2-yl)-4-propyl-1h-pyrazol-5-amine (CAS 1229025-36-8)
- Sitagliptin Impurity 26 (CAS 218609-00-8)
- (S)-2-Amino-1-(3-methoxypyrrolidin-1-yl)ethanone (CAS 1354002-49-5)
- N-(6-Oxo-1,6-dihydropyridazin-3-yl)-N-propylacetamide (CAS 88259-87-4)
- N-Ethylisobutylamine (CAS 13205-60-2)
- Semaglutide impurity 233 (CAS CATO-C4X-2226233)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com