N'-(3-chlorobenzoyl)-1-(3-fluorobenzyl)piperidine-4-carbohydrazide CAS 478259-07-3
| CAS No. | 478259-07-3 |
| Molecular Formula | C20H21ClFN3O2 |
| Molecular Weight | 389.85 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of N'-(3-chlorobenzoyl)-1-(3-fluorobenzyl)piperidine-4-carbohydrazide is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
N'-(3-chlorobenzoyl)-1-(3-fluorobenzyl)piperidine-4-carbohydrazide (CAS 478259-07-3), molecular formula C20H21ClFN3O2 and molecular weight 389.85 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, N'-(3-chlorobenzoyl)-1-(3-fluorobenzyl)piperidine-4-carbohydrazide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 389.85 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H21ClFN3O2 |
| Molecular Weight | 389.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related N Standards
- 4-{[2-(4-chlorobenzoyl)-5-(trifluoromethyl)pyridin-3-yl]oxy}phenol (CAS 338959-85-6)
- 6-(4-Chlorobenzoyl)-4-(3-chlorophenyl)quinolin-2(1H)-one (CAS 192187-32-9)
- 4-[5-(4-Chlorobenzoyl)-3-(pyridin-2-yl)thiophen-2-yl]morpholine (CAS 339023-17-5)
- 5-(4-(4-Chlorobenzoyl)piperazin-1-yl)-6-phenylpyridazin-3(2H)-one (CAS 477863-44-8)
- N'-(3-chlorobenzoyl)-8-methyl-8H-thieno[2,3-b]indole-2-carbohydrazide (CAS 477869-02-6)
- 5-[1-(3-Chlorobenzoyl)pyrrolidin-2-yl]-3-(4-methoxyphenyl)-1,2,4-oxadiazole (CAS 855129-92-9)
- 1-(4-Chlorobenzoyl)-4-{[(4-chlorophenyl)sulfanyl]methyl}piperidin-4-ol (CAS 478248-10-1)
- 3-[1-(4-Chlorobenzoyl)piperidin-4-yl]-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775454-98-2)
Recommended Standards
- Methyl 3-{[(4-chlorophenyl)sulfonyl]methyl}-4-(1H-pyrrol-1-yl)benzenecarboxylate (CAS 339016-40-9)
- N-(4-(((4-chlorophenyl)thio)methyl)phenyl)-2,4-difluorobenzamide (CAS 338398-87-1)
- 1,4-Bis(bromomethyl)-2-iodobenzene (CAS 60017-02-9)
- N-(4-(((4-chlorophenyl)thio)methyl)phenyl)-2,6-difluorobenzamide (CAS 321431-94-1)
- 3-(Dimethyl(3-(4-octylbenzamido)propyl)ammonio)propane-1-sulfonate (CAS 216667-49-1)
- 2-(Cyclohexyloxy)-3-nitropyridine (CAS 147143-55-3)
- 3-(4-Chlorophenyl)-2-cyanoacrylic acid (CAS 20374-46-3)
- Ticagrelor Impurity 9 (CAS 1445580-43-7)
- 4,6-Dichloro-5-fluoro-2-methylpyrimidine (CAS 105806-13-1)
- 5-Boc-amino-benzoimidazole (CAS 885270-97-3)
- ethyl 4-methoxy-5-methyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate (CAS 1860028-32-5)
- 5-Chloro-2-methoxybenzaldehyde (CAS 7035-09-8)
- ethyl 4-oxo-7-(trifluoromethyl)chromene-2-carboxylate (CAS 2530127-55-8)
- Mast Cell Degranulating (MCD) Peptide (CAS 32908-73-9)
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