Donepezil Impurity 48 CAS 4803-74-1
| CAS No. | 4803-74-1 |
| Molecular Formula | C17H15NO3 |
| Molecular Weight | 281.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Donepezil Impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Donepezil Impurity 48 (CAS 4803-74-1) is a certified pharmaceutical impurity reference standard with the molecular formula C17H15NO3 and a molecular weight of 281.31 g/mol.
Structurally, Donepezil Impurity 48 (C17H15NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 281.31 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C17H15NO3 |
| Molecular Weight | 281.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 1 |
Related Donepezil Standards
- Donepezil EP impurity D (CAS 4803-57-0)
- Donepezil Impurity 45 (CAS 844694-83-3)
- Donepezil Impurity 33 (E/Z Mixture) (CAS 149874-91-9)
- Donepezil Impurity 44 (CAS 1026443-48-0)
- Donepezil EP impurity A (CAS 120014-30-4)
- Donepezil Impurity 19 (CAS CATO-C4X-103919)
- Donepezil Impurity 75 (CAS CATO-C4X-103975)
- Donepezil impurity 01 (CAS 2452407-68-8)
Recommended Standards
- 362000-34-8 2-[(4,8-Dimethylquinazolin-2-yl)amino]-6-methylpyrimidin-4(3H)-one MFCD22374902 (CAS 362000-34-8)
- Carbamazepine Impurity 16 (CAS CATO-C4X-118116)
- 332074-12-1 2-[(4,7-Dimethylquinazolin-2-yl)amino]-6-methylpyrimidin-4(3H)-one MFCD22374899 (CAS 332074-12-1)
- Ruxolitinib Impurity 229 (CAS CATO-C4X-2058229)
- Indometacin EP Impurity E (CAS 807614-94-4)
- Dexamethasone Impurity 129 (CAS CATO-C4X-1165129)
- Sildenafil Impurity 285 (CAS CATO-C4X-1128285)
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- (E)-3-(1-((2,4-dimethoxyphenyl)amino)ethylidene)dihydrofuran-2(3H)-one (CAS 200932-30-5)
- 1,3,3-Trimethylcyclobutan-1-amine hydrochloride (CAS 2138586-43-1)
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- 1-(3-Nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione hydrochloride (CAS 152815-28-6)
- Boc-Cholecystokinin Octapeptide (desulfated) (A-1295.0001) (CAS 25687-34-7)
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