Afatinib Impurity 72 CAS 487060-47-9
| CAS No. | 487060-47-9 |
| Molecular Formula | C9H15N2O4P |
| Molecular Weight | 246.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Afatinib Impurity 72 (CAS 487060-47-9), a pharmacopoeial impurity reference standard (molecular formula C9H15N2O4P, MW 246.20 g/mol) used for the identification and quantification of trace impurities in APIs.
Afatinib Impurity 72 (C9H15N2O4P) contains an amide group, a phosphate ester group, a carboxylic acid group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO manufactures Afatinib Impurity 72 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H15N2O4P |
| Molecular Weight | 246.20 g/mol |
| Appearance | White to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 2 |
Related Afatinib Standards
- Afatinib Impurity 88 (CAS 2475095-43-1)
- Afatinib Impurity 74 (CAS CATO-C4X-100674)
- Afatinib Impurity 75 (CAS CATO-C4X-100675)
- Afatinib Impurity 64 (CAS CATO-C4X-100664)
- Afatinib impurity 86 (CAS CATO-C4X-100686)
- Afatinib Impurity 28 (CAS 17519-02-7)
- Afatinib Impurity 50 (CAS 137131-09-0)
- Afatinib Impurity 35 (CAS 6943-17-5)
Recommended Standards
- N5-(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (CAS 294873-69-1)
- Bumetanide Impurity 54 (CAS CATO-C4X-198654)
- Methyl 2-(3,4,4-trifluorobut-3-ene-1-sulfonyl)acetate (CAS 339020-20-1)
- Cytarabine-13C-15N2 (CAS CATO-C4X-20056)
- Sodium Cyclamate EP Impurity D (CAS 101-83-7)
- Sodium Valproate Impurity 15 (CAS 2163-48-6)
- Palbociclib Impurity 120 (CAS CATO-C4X-1125120)
- 4-Mercaptomethyl-piperidine-1-carboxylic acid benzyl ester (CAS 1353979-25-5)
- 8-tert-Butyl-4-(3,5-difluorobenzoyl)-1-oxa-4-azaspiro[4.5]decane-3-carboxylic acid (CAS 1326811-48-6)
- (S)-[(1-Phenylethyl)amino]acetic Acid (CAS 78397-14-5)
- tert-butyl (6-oxohexyl)carbamate (CAS 80860-42-0)
- 4-(5-Bromopyrimidin-1(6H)-yl)morpholine (CAS 84539-22-1)
- N-(2-Bromophenyl)-4-(2-pyridinyl)tetrahydro-1(2H)-pyrazinecarboxamide (CAS 335282-78-5)
- Dulaglutide (CAS 923950-08-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com