Afatinib Impurity 64 CAS CATO-C4X-100664
| CAS No. | CATO-C4X-100664 |
| Molecular Formula | C8H6FN3O3 |
| Molecular Weight | 211.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 211.15 g/mol gives Afatinib Impurity 64 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Afatinib Impurity 64 (CAS CATO-C4X-100664) is a certified pharmaceutical impurity reference standard with the molecular formula C8H6FN3O3 and a molecular weight of 211.15 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Afatinib Impurity 64 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 211.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Afatinib Impurity 64 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H6FN3O3 |
| Molecular Weight | 211.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Afatinib Standards
- Afatinib impurity 86 (CAS CATO-C4X-100686)
- Afatinib Impurity 28 (CAS 17519-02-7)
- Afatinib Impurity 50 (CAS 137131-09-0)
- Afatinib Impurity 35 (CAS 6943-17-5)
- Afatinib Impurity 75 (CAS CATO-C4X-100675)
- Afatinib Impurity 74 (CAS CATO-C4X-100674)
- Afatinib Impurity 39 (CAS 1117-71-1)
- Afatinib Impurity 56 (CAS CATO-C4X-100656)
Recommended Standards
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- Sofosbuvir Impurity 102 (CAS CATO-C4X-1052102)
- L-AP6 (CAS 78944-89-5)
- 2-NP-SCA 13C,15N2 (CAS 957509-32-9)
- Milnacipran impurity 01 (CAS 69160-65-2)
- Rasagiline Impurity 13 HCl (CAS 1175018-75-3)
- Atrasentan Impurity 150 (CAS 1058402-39-3)
- N-(Benzo[d]thiazol-2-yl)-2-((4-fluorophenyl)thio)acetamide (CAS 839696-71-8)
- Lifitegrast Impurity 84 (CAS CATO-C4X-240984)
- Xylazine Hydrochloride EP Impurity D (CAS 120077-91-0)
- 2-Bromo-3-methylanthracene-9,10-dione (CAS 84-44-6)
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- 4-Ethoxybenzene-1,3-diamine (CAS 5862-77-1)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com