Afatinib Impurity 74 CAS CATO-C4X-100674
| CAS No. | CATO-C4X-100674 |
| Molecular Formula | C11H14ClN3O |
| Molecular Weight | 239.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Afatinib Impurity 74 (CAS CATO-C4X-100674, C11H14ClN3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Afatinib Impurity 74 (C11H14ClN3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Afatinib Impurity 74 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H14ClN3O |
| Molecular Weight | 239.70 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Afatinib Standards
- Afatinib Impurity 75 (CAS CATO-C4X-100675)
- Afatinib Impurity 72 (CAS 487060-47-9)
- Afatinib Impurity 88 (CAS 2475095-43-1)
- Afatinib Impurity 64 (CAS CATO-C4X-100664)
- Afatinib impurity 86 (CAS CATO-C4X-100686)
- Afatinib Impurity 28 (CAS 17519-02-7)
- Afatinib Impurity 50 (CAS 137131-09-0)
- Afatinib Impurity 35 (CAS 6943-17-5)
Recommended Standards
- tert-Butyl 4-chlorobenzylidenecarbamate (CAS 779342-75-5)
- Palbociclib Impurity 46 (CAS 1244949-62-9)
- n-{2-[4-(2-chloroacetyl)phenyl]ethyl}acetamide (CAS 63077-41-8)
- Dasatinib Impurity 18 (CAS CATO-C4X-160718)
- Oxymetazoline Impurity 13 (CAS CATO-C4X-172313)
- Sorafenib Impurity 57 (CAS 99970-10-2)
- Nebivolol Impurity 32（SS,RS）or（SR,SS） (CAS 119365-25-2)
- Platinum,[ethanedioato(2-)-O,O'](1,3-propanediamine-N,N')- (CAS 71418-09-2)
- 2-([1,1'-Biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid (CAS 130507-59-4)
- (1-(3-(Trifluoromethyl)benzyl)-1H-1,2,3-triazol-4-yl)methanol (CAS 952183-25-4)
- 3-Amino-6-fluoro-1H-indazole (CAS 404827-75-4)
- (4-(2-(Trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-yl)methanamine hydrochloride (CAS 1380300-49-1)
- N-(1,1-Dioxidotetrahydrothiophen-3-yl)-7-methoxybenzofuran-2-carboxamide (CAS 951927-15-4)
- Fragment-[9-31]-Semaglutide (CAS CATO-C4X-2226181)
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