Dimenhydrinate EP Impurity E CAS 4921-49-7
| CAS No. | 4921-49-7 |
| Molecular Formula | C8H9ClN4O2 |
| Molecular Weight | 228.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Dimenhydrinate EP Impurity E.
As a process- or degradation-related impurity, Dimenhydrinate EP Impurity E (CAS 4921-49-7, C8H9ClN4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Dimenhydrinate EP Impurity E (C8H9ClN4O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Dimenhydrinate EP Impurity E under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H9ClN4O2 |
| Molecular Weight | 228.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Dimenhydrinate Standards
- Dimenhydrinate Impurity(8-chloro-1-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione) (CAS 6136-36-3)
- Dimenhydrinate EP Impurity I (CAS 91-01-0)
- Dimenhydrinate EP Impurity A (CAS 58-55-9)
- Dimenhydrinate Impurity C2 (CAS 2212-35-3)
- Dimenhydrinate Impurity N4 (CAS 1797911-12-6)
- Dimenhydrinate EP Impurity K (CAS 574-42-5)
- Dimenhydrinate Impurity 4 (CAS 33120-34-2)
- Dimenhydrinate Impurity 6 (CAS 14177-81-2)
Recommended Standards
- Minoxidil Impurity 25 (CAS 7148-63-2)
- 1-(2-Chloro-6-fluorophenyl)cyclobutanecarboxylic Acid (CAS 1037131-07-9)
- 330558-88-8 7-(2-Chloroethyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione MFCD01932692 (CAS 330558-88-8)
- N-(2-Chloroethyl)-2-oxooxazolidine-3-sulfonamide (CAS 116943-69-2)
- (1R,3s,5S)-Ipratropium Impurity 39 (CAS CATO-C4X-166539)
- Mosapride Impurity 22 (CAS CATO-C4X-104422)
- Finasteride Impurity 38 (CAS CATO-C4X-164538)
- 4-(6-Amino-1H-benzo[d]imidazol-2-yl)butan-2-ol dihydrochloride (CAS 435342-12-4)
- (S)-4-Benzyl-3-propanoylthiazolidine-2-thione (CAS 263764-23-4)
- (3-((Trimethylsilyl)ethynyl)phenyl)methanamine (CAS 615288-77-2)
- 3-(2,4-Dichlorophenyl)-5-methyl-4,5-dihydroisoxazole-5-carboxylic acid (CAS 1326815-54-6)
- Bis[2-phenylpyridine][4,4'-diamino-5,5'-dimethyl-2,2'-bipyridine] iridium(III) hexafluorophosphate (CAS 2489240-33-5)
- N,N-Dimethyl-N-nonylnonan-1-aminium chloride (CAS 23375-64-6)
- D-Val23-Tirzepatide (CAS CATO-CPTD788911)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com