Dimenhydrinate Impurity(8-chloro-1-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione) CAS 6136-36-3
| CAS No. | 6136-36-3 |
| Molecular Formula | C6H3ClN4O2 |
| Molecular Weight | 198.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Dimenhydrinate Impurity(8-chloro-1-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione) (CAS 6136-36-3, C6H3ClN4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C6H3ClN4O2, Dimenhydrinate Impurity(8-chloro-1-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 198.57 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H3ClN4O2 |
| Molecular Weight | 198.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Dimenhydrinate Standards
- Dimenhydrinate EP Impurity I (CAS 91-01-0)
- Dimenhydrinate EP Impurity A (CAS 58-55-9)
- Dimenhydrinate EP Impurity E (CAS 4921-49-7)
- Dimenhydrinate Impurity C2 (CAS 2212-35-3)
- Dimenhydrinate Impurity N4 (CAS 1797911-12-6)
- Dimenhydrinate EP Impurity K (CAS 574-42-5)
- Dimenhydrinate Impurity 6 (CAS 14177-81-2)
- Dimenhydrinate EP Impurity C Hydrate (CAS 5743-12-4)
Recommended Standards
- 7-Chloro-5-nitro-3H-imidazo[4,5-b]pyridine (CAS 878011-46-2)
- 5-Chloro-1-ethyl-3-(trifluoromethyl)-1H-pyrazole 665026-47-1 KS-00003TFI (CAS 665026-47-1)
- 7-Chloro-3-nitro-1H-pyrazolo[3,4-c]pyridine (CAS 957760-19-9)
- Ganciclovir impurity 22 (CAS CATO-C4X-102122)
- Pentoxyverine Impurity 2 (CAS CATO-C4X-22702)
- Beraprost Impurity 32 (CAS CATO-C4X-218432)
- Melphalan EP Impurity B DiHCl (CAS CATO-C4X-198820)
- 3-(4-Methylphenyl)-3-(trifluoromethyl)diazirine (CAS 87736-85-4)
- Lisinopril Impurity 18 (CAS CATO-C4X-168118)
- 3-(4-Chlorophenyl)-3-(4-fluorophenyl)propanoic acid (CAS 80272-10-2)
- Ticagrelor Impurity 66 HCl (CAS CATO-C4X-109366)
- 8-Bromoimidazo[1,2-c]pyrimidine (CAS 1049001-84-4)
- N-(cyclohexylmethyl)propan-2-amine (CAS 54717-04-3)
- Semaglutide Impurity 131 (CAS 2618647-80-4)
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