Memantine impurity 58 CAS 49764-18-3
| CAS No. | 49764-18-3 |
| Molecular Formula | C20H30O |
| Molecular Weight | 286.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Memantine impurity 58 is closely related to a steroid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Memantine impurity 58 (CAS 49764-18-3), a pharmacopoeial impurity reference standard (molecular formula C20H30O, MW 286.45 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Memantine impurity 58 (C20H30O) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Memantine impurity 58 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H30O |
| Molecular Weight | 286.45 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
Related Memantine Standards
- Memantine Glycine tert-Butyl Ester (CAS 1537550-23-4)
- Memantine Impurity 62 (CAS 14931-70-5)
- Memantine Impurity 63 (CAS 875211-09-9)
- Memantine impurity 57 (CAS CATO-C4X-105857)
- Memantine Impurity 61 (CAS 111035-07-5)
- Memantine Dedimethyl Dibromo (CAS 1797133-04-0)
- Memantine Impurity 64 (CAS 2123482-13-1)
- Memantine Impurity 66 (CAS CATO-C4X-105866)
Recommended Standards
- Ferruginol (CAS 514-62-5)
- Vitamin A EP Impurity C（Mixture of Z and E Isomers） (CAS 16729-22-9 ((3E)-Isomer))
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- Vitamin A (CAS 11103-57-4)
- Lidocaine EP Impurity E (CAS 745798-07-6)
- Prednisolone impurity 56 (CAS CATO-C4X-173756)
- Crizotinib Impurity 73 (CAS CATO-C4X-102573)
- 2,6-Dimethyl-1,2,3,4-tetrahydroquinoline (CAS 16078-45-8)
- 1-(2,6-Dichloro-4-(perfluoropropan-2-yl)phenyl)-4-iodo-1h-pyrazole (CAS 2084123-37-3)
- 1-(6-phenylpyrimidin-4-yl)cyclopropane-1-carboxylic acid (CAS 1706448-87-4)
- [rel-(1R,5S,6r)-3-benzyl-3-azabicyclo[3.1.0]hexan-6-yl]methanol (CAS 134575-07-8)
- 5,6-Dimethyl-2-phenylpyrazolo[1,5-a]pyrimidin-7-ol (CAS 158501-30-5)
- Thieno[2,3-b]pyridin-2-amine (CAS 1057326-75-6)
- Neuropeptide VF (124-131) (human) (CAS 311309-27-0)
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