Memantine Impurity 63 CAS 875211-09-9
| CAS No. | 875211-09-9 |
| Molecular Formula | C14H22BrNO |
| Molecular Weight | 300.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Memantine Impurity 63 (C14H22BrNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Memantine Impurity 63 (CAS 875211-09-9) is a certified pharmaceutical impurity reference standard with the molecular formula C14H22BrNO and a molecular weight of 300.23 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H22BrNO |
| Molecular Weight | 300.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Memantine Standards
- Memantine Glycine tert-Butyl Ester (CAS 1537550-23-4)
- Memantine impurity 57 (CAS CATO-C4X-105857)
- Memantine Impurity 61 (CAS 111035-07-5)
- Memantine Dedimethyl Dibromo (CAS 1797133-04-0)
- Memantine impurity 58 (CAS 49764-18-3)
- Memantine Impurity 66 (CAS CATO-C4X-105866)
- Memantine Impurity 62 (CAS 14931-70-5)
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Recommended Standards
- Tetraethyl ethene-1,1-diylbis(phosphonate) (CAS 37465-31-9)
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- Ramelteon Impurity 31 (CAS 1204581-50-9)
- Cholecalciferol Impurity 12 (CAS 156965-15-0)
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- Baclofen Impurity 75 (CAS CATO-C4X-101275)
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- 6-Methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline (CAS 2096334-29-9)
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