Lamotrigine EP Impurity E CAS 50-45-3
| CAS No. | 50-45-3 |
| Molecular Formula | C7H4Cl2O2 |
| Molecular Weight | 191.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Lamotrigine EP Impurity E (C7H4Cl2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Lamotrigine EP Impurity E (CAS 50-45-3), a pharmacopoeial impurity reference standard (molecular formula C7H4Cl2O2, MW 191.01 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4Cl2O2 |
| Molecular Weight | 191.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Lamotrigine Standards
- Lamotrigine Impurity 7 (CAS 31273-66-2)
- Lamotrigine Impurity 16 (CAS 608-27-5)
- Lamotrigine Impurity 16 (CAS 2250242-15-8)
- Lamotrigine Impurity 17 (CAS 887354-37-2)
- Lamotrigine Impurity 23 (CAS 30885-95-1)
- Lamotrigine 6-(3,4-Dichlorophenyl)-1,2,4-triazine-3,5-diamine Impurity (CAS 36518-85-1)
- Lamotrigine EP Impurity B and Lamotrigine EP Impurity C (CAS 84689-20-3)
- Lamotrigine Impurity 10 (CAS 77668-43-0)
Recommended Standards
- Furosemide EP Impurity E (CAS 50-84-0)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com