3-(4-(2-Chloroacetamido)phenyl)propanoic acid CAS 500336-83-4
| CAS No. | 500336-83-4 |
| Molecular Formula | C11H12ClNO3 |
| Molecular Weight | 241.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(4-(2-Chloroacetamido)phenyl)propanoic acid.
3-(4-(2-Chloroacetamido)phenyl)propanoic acid (CAS 500336-83-4), molecular formula C11H12ClNO3 and molecular weight 241.67 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-(4-(2-Chloroacetamido)phenyl)propanoic acid (C11H12ClNO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H12ClNO3 |
| Molecular Weight | 241.67 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloroacetamido Standards
- Methyl 2-(2-chloroacetamido)-2-phenylacetate (CAS 100508-78-9)
- 3-(3-(2-Chloroacetamido)phenyl)propanoic acid (CAS 1221792-58-0)
- 3-((2-Chloroacetamido)methyl)-4-methylbenzoic acid (CAS 727673-69-0)
- 3-(2-Chloroacetamido)-3-phenylpropanoic acid (CAS 607737-27-9)
- Ethyl 2-(2-chloroacetamido)benzoate (CAS 6307-66-0)
- Ethyl 4-(2-chloroacetamido)benzoate (CAS 26226-72-2)
- Methyl 3-(2-chloroacetamido)-4-methylbenzoate (CAS 54941-43-4)
- Methyl 4-[(2-chloroacetamido)methyl]benzoate (CAS 379255-44-4)
Recommended Standards
- 3-(4-Chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propane-1,2-diol (CAS 80765-76-0)
- 3-(4-Chloro-benzoylamino)-propionic acid methyl ester (CAS 854137-36-3)
- 2-Chloro-N-(2,3-dihydro-1,4-benzodioxin-6-yl)propanamide (CAS 554438-61-8)
- N-Acetyl-DL-p-chlorophenylalanine (CAS 23434-92-6)
- 1-Bromo-4-chloro-2-(trifluoromethoxy)benzene (CAS 1402672-86-9)
- Tert-butyl (1R,3R,5R)-3-(bromomethyl)-2-azabicyclo[3.1.0]Hexane-2-carboxylate (CAS 2227198-68-5)
- 1-(Chloromethyl)bicyclo[2.2.1]Heptane (CAS 75637-42-2)
- (Z)-Dodec-9-en-1-ol (CAS 35148-18-6)
- 6,7-Diethoxy-1-methyl-3,4-dihydroisoquinoline (CAS 99155-80-3)
- 1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)ethanone (CAS 1244949-16-3)
- 2-((2-Ethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-phenylacetamide (CAS 850905-05-4)
- 5-Methyl-2-(methylthio)-[1,2,4]triazolo[1,5-a]pyrimidine (CAS 56347-12-7)
- 5,6-difluorobenzo[d]oxazol-2(3H)-one (CAS 871367-13-4)
- Semaglutide impurity 260 (CAS CATO-C4X-2226260)
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