Ambroxol EP Impurity A CAS 50739-76-9
| CAS No. | 50739-76-9 |
| Molecular Formula | C7H7Br2NO |
| Molecular Weight | 280.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C7H7Br2NO, Ambroxol EP Impurity A contains an amide group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 280.94 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Ambroxol EP Impurity A (CAS 50739-76-9, C7H7Br2NO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ambroxol EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H7Br2NO |
| Molecular Weight | 280.94 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Ambroxol Standards
- Ambroxol Impurity 49 (CAS 86379-71-7)
- Ambroxol impurity 116 (CAS 1373889-89-4)
- Ambroxol Impurity 31 (CAS 42460-62-8)
- Ambroxol Impurity 20 (CAS 609-85-8)
- Ambroxol Impurity 37 (CAS CATO-C4X-108537)
- Ambroxol Impurity 83 (CAS CATO-C4X-108583)
- Ambroxol Impurity 28 (Ambroxol Monobromo) (CAS 101900-43-0)
- Ambroxol Impurity 85 (CAS CATO-C4X-108585)
Recommended Standards
- 2,4-Dibromo-6-methoxyaniline (CAS 88149-47-7)
- 3,5-Dibromo-1-(cyclopropylmethyl)-1H-1,2,4-triazole (CAS 1240571-94-1)
- 2,6-Dibromo-4-methoxyaniline (CAS 95970-05-1)
- 3,5-Dibromo-2-hydrazinyl-6-methylpyridine (CAS 1820706-07-7)
- Baclofen Impurity 58 (CAS CATO-C4X-101258)
- Blonanserin Impurity 2 DiHCl (CAS 1648791-23-4(free base))
- Cimetidine EP Impurity C (CAS 77076-18-7)
- N,N-Dimethyl-1-(4-nitrophenyl)piperidin-4-amine (CAS 211247-60-8)
- 6-(3-Bromophenoxy)nicotinic acid (CAS 953731-93-6)
- 1-Piperidin-1-ylacetone (CAS 6784-61-8)
- n-Cyclopentyl-2-methylcyclohexan-1-amine (CAS 1019629-78-7)
- NCG31955 (CAS 842112-70-3)
- 1-(4-(Benzo[d]oxazol-2-yl)piperazin-1-yl)-2-(2,3-dihydro-1H-inden-1-yl)ethan-1-one (CAS 727685-73-6)
- Insulin Degludec Impurity 18 (CAS CATO-C4X-215718)
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