Codeine Phosphate Hemihydrate EP Impurity K CAS 508-54-3
| CAS No. | 508-54-3 |
| Molecular Formula | C18H19NO4 |
| Molecular Weight | 313.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Codeine Phosphate Hemihydrate EP Impurity K (C18H19NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Codeine Phosphate Hemihydrate EP Impurity K (CAS 508-54-3), a pharmacopoeial impurity reference standard (molecular formula C18H19NO4, MW 313.35 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Codeine Phosphate Hemihydrate EP Impurity K meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H19NO4 |
| Molecular Weight | 313.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Codeine Standards
- Codeine EP Impurity A (CAS 2859-16-7)
- Codeine-D6 (CAS 1007844-34-9)
- Codeine-d3 (CAS 70420-71-2)
- Codeine (CAS 76-57-3)
- Codeine 6-Methanesulfonate (1.0mg/ml in Acetonitrile) (CAS 22952-80-3)
- Codeine-6β-D-glucuronide (CAS 20736-11-2)
- Codeine-6-ß-D-glucuronide-D3 (CAS 219533-59-2)
- Codeine β-D-Glucuronide Triacetate Methyl Ester (1.0mg/ml in Acetonitrile) (CAS 20736-10-1)
Recommended Standards
- Ciprofloxacin EP Impurity B (CAS 93107-11-0)
- Indobufen Impurity 1 (CAS CATO-C4X-17921)
- Telmisartan Impurity 63 (CAS CATO-C4X-135963)
- Indobufen Impurity 40 (CAS 203313-55-7)
- Neratinib Impurity 20 (CAS CATO-C4X-113420)
- Pranoprofen Impurity 22 (CAS 146330-68-9)
- Chlorphenamine EP Impurity D (CAS 65676-21-3)
- 3-Amino-4-(cyclohexyloxy)phenol (CAS 1243393-44-3)
- Alpha,Alpha,Alpha,4-Tetrachlorotoluene (CAS 5216-25-1)
- 2-(Pyridin-3-yl)tetrahydro-2H-thiopyran-2-carbohydrazide (CAS 1352523-09-1)
- 1-Methyl-3,4-dihydroisoquinoline hydrochloride (CAS 26210-39-9)
- 4-Cyano-5-(2-cyanoacetamido)-N,N-diethyl-3-methylthiophene-2-carboxamide (CAS 581780-63-4)
- Vernakalant Impurity 7 (CAS 795282-27-8)
- Semaglutide impurity 214 (CAS CATO-C4X-2226214)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com