Codeine EP Impurity A CAS 2859-16-7
| CAS No. | 2859-16-7 |
| Molecular Formula | C19H23NO3 |
| Molecular Weight | 313.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Codeine EP Impurity A.
As a process- or degradation-related impurity, Codeine EP Impurity A (CAS 2859-16-7, C19H23NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Codeine EP Impurity A (C19H23NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 313.39 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H23NO3 |
| Molecular Weight | 313.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Codeine Standards
- Codeine Phosphate Hemihydrate EP Impurity K (CAS 508-54-3)
- Codeine-D6 (CAS 1007844-34-9)
- Codeine-d3 (CAS 70420-71-2)
- Codeine (CAS 76-57-3)
- Codeine 6-Methanesulfonate (1.0mg/ml in Acetonitrile) (CAS 22952-80-3)
- Codeine-6β-D-glucuronide (CAS 20736-11-2)
- Codeine-6-ß-D-glucuronide-D3 (CAS 219533-59-2)
- Codeine β-D-Glucuronide Triacetate Methyl Ester (1.0mg/ml in Acetonitrile) (CAS 20736-10-1)
Recommended Standards
- Codeimethine (CAS 23950-06-3)
- Diethyl 2-acetamido-2-(hept-6-en-1-yl)malonate (CAS 924309-92-2)
- Armepavine (CAS 524-20-9)
- Erysotrin (CAS 27740-43-8)
- Desloratadine Impurity 22 (CAS 119410-05-8)
- Lenvatinib Impurity 176 (CAS CATO-C4X-1140176)
- Roxadustat Impurity 81 (CAS CATO-C4X-221381)
- 1-methanesulfonyl-2-methylpropan-2-amine hydrochloride (CAS 409095-77-8)
- N,N-Bis(diphenylphosphino)amine (CAS 2960-37-4)
- 2-Bromo-4-chloro-5-isopropylbenzonitrile (CAS 2416992-44-2)
- 951886-04-7 Ethyl 4-[4-(N,N-Diethylamino)phenyl]-4-oxobutanoate MFCD09801909 (CAS 951886-04-7)
- trans-4-Morpholinotetrahydrofuran-3-amine dihydrochloride (CAS 1609402-69-8)
- (5Z,9E)-3,10-Dimethyl-4,7,8,11-tetrahydrocyclodeca[b]furan-6-carboxylic acid (CAS 32180-36-2)
- Semaglutide impurity 244(Fmoc-His(Fmoc)-Aib-OH) (CAS CATO-C4X-2226244)
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