Codeine 6-Methanesulfonate (1.0mg/ml in Acetonitrile) CAS 22952-80-3
| CAS No. | 22952-80-3 |
| Molecular Formula | C19H23NO5S |
| Molecular Weight | 377.45 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Codeine 6-Methanesulfonate (1.0mg/ml in Acetonitrile) (CAS 22952-80-3), molecular formula C19H23NO5S and molecular weight 377.45 g/mol, is a CATO reference standard with documented purity and traceability.
Codeine 6-Methanesulfonate (1.0mg/ml in Acetonitrile) (C19H23NO5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Codeine 6-Methanesulfonate (1.0mg/ml in Acetonitrile) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H23NO5S |
| Molecular Weight | 377.45 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Codeine Standards
- Codeine EP Impurity A (CAS 2859-16-7)
- Codeine Phosphate Hemihydrate EP Impurity K (CAS 508-54-3)
- Codeine-D6 (CAS 1007844-34-9)
- Codeine-d3 (CAS 70420-71-2)
- Codeine (CAS 76-57-3)
- Codeine-6β-D-glucuronide (CAS 20736-11-2)
- Codeine-6-ß-D-glucuronide-D3 (CAS 219533-59-2)
- Codeine β-D-Glucuronide Triacetate Methyl Ester (1.0mg/ml in Acetonitrile) (CAS 20736-10-1)
Recommended Standards
- Cinuperone (CAS 82117-51-9)
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- (R)-tert-Butyl (1-(2-bromo-4-chlorophenyl)ethyl)carbamate (CAS 1799438-97-3)
- Semaglutide Impurity 130 (CAS 1188328-40-6)
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