Norepinephrine impurity 148 CAS 50988-14-2
| CAS No. | 50988-14-2 |
| Molecular Formula | C9H11NO3 |
| Molecular Weight | 181.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Norepinephrine impurity 148 (C9H11NO3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Norepinephrine impurity 148 (CAS 50988-14-2) is a certified pharmaceutical impurity reference standard with the molecular formula C9H11NO3 and a molecular weight of 181.19 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H11NO3 |
| Molecular Weight | 181.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Nitrogen Atoms | 1 |
Related Norepinephrine Standards
- Norepinephrine Impurity 19 (CAS CATO-C4X-151419)
- Norepinephrine Impurity 101 (CAS 32655-70-2)
- Norepinephrine Impurity 111 (CAS 2947-04-8)
- Norepinephrine impurity 54 (CAS 1932110-67-2)
- Norepinephrine Impurity 17 (CAS CATO-C4X-151417)
- Norepinephrine impurity 150 (CAS CATO-C4X-1514150)
- Norepinephrine Impurity 158 (CAS CATO-C4X-1514158)
- Norepinephrine Impurity 51 (CAS 73917-81-4)
Recommended Standards
- Allopurinol impurity 29 (CAS CATO-C4X-145829)
- Famotidine impurity 69 (CAS 850864-53-8)
- Formoterol Impurity 31 (CAS 477552-94-6)
- Metoprolol Impurity 26 (CAS 69628-98-4)
- Bevantolol Impurity 28 (CAS CATO-C4X-241128)
- Tenofovir Disoproxil Impurity 46 (CAS CATO-C4X-107646)
- Irinotecan EP Impurity A HCl Trihydrate (CAS 158406-44-1)
- 4-[2-(2-Chlorophenyl)-4-methyl-1,3-thiazol-5-yl]pyrimidin-2-amine (CAS 499795-83-4)
- Nitrofurantoin impurity 1 (CAS CATO-C4X-30861)
- Sulfo-SNPB (CAS 1193111-37-3)
- (R)-3-Bromo-2-methyl-2-(phenylamino)propanoic acid, 97% (CAS 1212117-73-1)
- 1-(Difluoromethoxy)-3-iodo-2-methylbenzene (CAS 1261825-62-0)
- 2-Ethynyl-3-fluorobenzonitrile (CAS 1848959-59-0)
- Cycloaspeptide A (CAS 109171-13-3)
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