Lidocaine Impurity 27 CAS 5177-35-5
| CAS No. | 5177-35-5 |
| Molecular Formula | C10H12ClNO |
| Molecular Weight | 197.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Lidocaine Impurity 27 (CAS 5177-35-5, C10H12ClNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Lidocaine Impurity 27 (C10H12ClNO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 197.66 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Lidocaine Impurity 27 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H12ClNO |
| Molecular Weight | 197.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Lidocaine Standards
- Lidocaine EP Impurity H (CAS 1131-01-7)
- Lidocaine Impurity 41 (CAS 2903-48-2)
- Lidocaine Impurity 80 (CAS CATO-C4X-167980)
- Lidocaine EP Impurity D (CAS 7728-40-7)
- Lidocaine Impurity 30 (CAS 21236-54-4)
- Lidocaine impurity 66 (CAS CATO-C4X-167966)
- Lidocaine Impurity 77 (CAS CATO-C4X-167977)
- Lidocaine Impurity 50 (CAS 27794-54-3)
Recommended Standards
- Amorolfine Impurity 86 (CAS 27110-75-4)
- Lorcaserin Impurity 4 (CAS 1421747-19-4)
- Etomidate impurity 64 (CAS 36293-00-2)
- Palbociclib Impurity 88 (CAS 868591-58-6)
- Vonoprazan Impurity 67 (CAS CATO-C4X-102067)
- Urapidil Impurity 62 HCl (CAS CATO-C4X-192462)
- Fluocinolone Acetonide Impurity 46 (CAS CATO-C4X-238146)
- 5-((4-Ethylphenyl)sulfonyl)-2-mercaptopyrimidin-4-ol (CAS 1255782-97-8)
- 6-chloro-1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline (CAS 1505757-71-0)
- N-(2-(aminomethyl)pyridin-4-yl)acetamide (CAS 1824097-79-1)
- 3-Chloro-2-mercapto-5-(trifluoromethyl)pyridine 3-Chloro-2-sulphanyl-5-(trifluoromethyl)pyridine 3-chloro-5-(trifluoromethyl)pyridine-2-thiol 76041-74-2 (CAS 76041-74-2)
- 3-Chloro-5-((3,4-dichlorobenzyl)sulfinyl)-1,2,4-thiadiazole (CAS 845879-22-3)
- Dapoxetine Impurity 103 (CAS 1135682-44-8)
- Semaglutide impurity 47 (CAS CATO-C4X-222647)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com