Palbociclib Impurity 88 CAS 868591-58-6
| CAS No. | 868591-58-6 |
| Molecular Formula | C9H12ClN3 |
| Molecular Weight | 197.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Palbociclib Impurity 88 (CAS 868591-58-6, C9H12ClN3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Palbociclib Impurity 88 (C9H12ClN3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H12ClN3 |
| Molecular Weight | 197.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Palbociclib Standards
- Palbociclib Impurity 174 (CAS CATO-C4X-1125174)
- Palbociclib Impurity 1 (CAS 39856-50-3)
- Palbociclib Impurity 30 (CAS 909712-10-3)
- Palbociclib Impurity 172 (CAS CATO-C4X-1125172)
- Palbociclib Impurity 43 (CAS 51534-82-8)
- Palbociclib Impurity 42 (CAS 51534-87-3)
- Palbociclib Impurity 44 (CAS CATO-C4X-112544)
- Palbociclib Impurity 44 (CAS 82205-58-1)
Recommended Standards
- Lorcaserin Impurity 4 (CAS 1421747-19-4)
- Tofacitinib Impurity 130 (CAS 2564-07-0)
- Amorolfine Impurity 86 (CAS 27110-75-4)
- 2-Chloro-N-phenethylacetamide (CAS 13156-95-1)
- Regorafenib EP Impurity B (CAS 2141961-84-2)
- Fruquintinib Impurity 1 (CAS CATO-C4X-30371)
- Timolol Impurity 19 Maleate (CAS CATO-C4X-149619)
- Ethyl 4-(benzylamino)-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (CAS 160034-51-5)
- tert-butyl 2-methylbutanoate (CAS 16537-12-5)
- Labetalol Impurity 68 (CAS CATO-C4X-246668)
- 3-(2-Chloropropanoyl)-1-(propan-2-yl)urea (CAS 879319-32-1)
- Benzyl N-(3-chloro-5-nitrophenyl)carbamate (CAS 1881291-62-8)
- 2-(4-(Naphthalen-2-ylsulfonyl)piperazin-1-yl)pyrimidine (CAS 256417-34-2)
- Semaglutide impurity 01 (CAS 1998701-31-7)
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