Etoposide EP Impurity M CAS 518-28-5
| CAS No. | 518-28-5 |
| Molecular Formula | C22H22O8 |
| Molecular Weight | 414.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Etoposide EP Impurity M is closely related to a flavonoid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Etoposide EP Impurity M (CAS 518-28-5, C22H22O8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, Etoposide EP Impurity M is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 414.41 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Etoposide EP Impurity M meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H22O8 |
| Molecular Weight | 414.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Etoposide Standards
- Etoposide EP Impurity J (CAS 118356-05-1)
- Etoposide Impurity 25 (CAS CATO-C4X-202425)
- Etoposide Impurity 35 (CAS CATO-C4X-202435)
- Etoposide Impurity 38 (CAS CATO-C4X-202438)
- Etoposide Impurity 31 (CAS CATO-C4X-202431)
- Etoposide EP Impurity H (CAS 102306-95-6)
- Etoposide EP Impurity L (CAS 40505-27-9)
- Etoposide Impurity 29 (CAS CATO-C4X-202429)
Recommended Standards
- Venetola Impurity 19 (CAS CATO-C4X-249519)
- epi-Sancycline (CAS CATO-C4X-169949)
- Ozenoxacin Impurity 77 (CAS CATO-C4X-279677)
- Minocycline EP Impurity B (CAS 808-26-4)
- Ketotifen Impurity 30 (CAS CATO-C4X-204630)
- Formoterol EP Impurity B (Trifluoroacetic Acid) (CAS CATO-C4X-152532)
- Imidapril Impurity 4 (CAS CATO-C4X-24394)
- 5-(4,4-difluorocyclohexyl)-1,3,4-oxadiazol-2-amine (CAS 1552763-97-9)
- tert-Butyl 5-methyl-3,4-dihydropyridine-1(2H)-carboxylate (CAS 178172-28-6)
- tert-Butyl 3-amino-3-(4-fluorophenyl)azetidine-1-carboxylate (CAS 2156173-79-2)
- 6-Ethyl-7-(4-methylthiazol-2-yl)-5H-thiazolo[3,2-a]pyrimidin-5-one (CAS 918891-46-0)
- 2-Methyl-1H-benzimidazole-1-acetic acid (CAS 40332-17-0)
- 2-(4-Amino-1-hydroxycyclohexyl)acetic acid (CAS 1519459-85-8)
- Semaglutide impurity 34 (CAS CATO-C4X-222634)
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