2-Chloro-N-(2,4-dimethoxyphenyl)quinazolin-4-amine CAS 524033-57-6
| CAS No. | 524033-57-6 |
| Molecular Formula | C16H14ClN3O2 |
| Molecular Weight | 315.75 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Structurally, 2-Chloro-N-(2,4-dimethoxyphenyl)quinazolin-4-amine (C16H14ClN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 315.75 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
2-Chloro-N-(2,4-dimethoxyphenyl)quinazolin-4-amine (CAS 524033-57-6) is a high-purity analytical reference standard with the molecular formula C16H14ClN3O2 and a molecular weight of 315.75 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H14ClN3O2 |
| Molecular Weight | 315.75 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
- 2-Chloro-N-(2,3-dimethoxyphenyl)quinazolin-4-amine (CAS 827030-60-4)
- 2-Chloro-N-(2,5-dimethoxyphenyl)quinazolin-4-amine (CAS 827030-61-5)
- 2-Chloro-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)nicotinamide (CAS 920506-35-0)
- 2-Chloro-N-(3,4-dimethoxyphenyl)quinazolin-4-amine (CAS 827030-99-9)
- Ethyl 2-hydroxy-3-methylpentanoate (CAS 24323-38-4)
- 3-(2,3-Dimethylbenzofuran-5-yl)-3H-[1,2,3]triazolo[4,5-b]pyridine (CAS 62490-32-8)
- 4,6-Dimethylheptan-3-one (CAS 40239-30-3)
- 3-(2,6-dichlorophenyl)-1H-pyrrole-2-carboxylic acid (CAS 1520810-96-1)
- 2-(3-methylpyrrolidin-1-yl)acetic acid hydrochloride (CAS 1803589-83-4)
- 3-Bromo-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine (CAS 226085-18-3)
- [(E)-but-1-enyl]phosphonic acid (CAS 443118-99-8)
- 5-Chloro-1-methylpyridin-2(1H)-one (CAS 4214-78-2)
- 3,7-Dimethyl-3,7,11-triazaspiro[5.6]Dodecane (CAS 1268334-80-0)
- Semaglutide Impurity 162 (x TFA Salt) (CAS CATO-C4X-2226162)
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