methyl 2-({[2-chloro-4-(trifluoromethyl)pyrimidin-5-yl]carbonyl}amino)thiophene-3-carboxylate CAS 524924-27-4
| CAS No. | 524924-27-4 |
| Molecular Formula | C12H7ClF3N3O3S |
| Molecular Weight | 365.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 365.72 g/mol gives methyl 2-({[2-chloro-4-(trifluoromethyl)pyrimidin-5-yl]carbonyl}amino)thiophene-3-carboxylate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies methyl 2-({[2-chloro-4-(trifluoromethyl)pyrimidin-5-yl]carbonyl}amino)thiophene-3-carboxylate (CAS 524924-27-4), a certified reference material (molecular formula C12H7ClF3N3O3S, MW 365.72 g/mol) for analytical method development and quality control.
methyl 2-({[2-chloro-4-(trifluoromethyl)pyrimidin-5-yl]carbonyl}amino)thiophene-3-carboxylate (C12H7ClF3N3O3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), methyl 2-({[2-chloro-4-(trifluoromethyl)pyrimidin-5-yl]carbonyl}amino)thiophene-3-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H7ClF3N3O3S |
| Molecular Weight | 365.72 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related methyl Standards
- 2-(1-{[2-chloro-5-(trifluoromethyl)phenyl]amino}ethylidene)-2,3-dihydro-1H-indene-1,3-dione (CAS 843636-53-3)
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- (1-{4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-2-nitroethenyl)(methyl)amine (CAS 1823194-64-4)
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- 5-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}methyl)-N-[(1E)-(hydroxyamino)methylidene]-4,5-dihydro-1,2-oxazole-3-carboxamide (CAS 338410-26-7)
- 5-((2-(2-Chloro-6-fluorophenyl)-3H-imidazo[4,5-c]pyridin-4-yl)amino)pyrazine-2-carbonitrile (CAS 1334407-73-6)
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Recommended Standards
- (2E,5Z)-5-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methylidene}-3-methyl-2-(nitromethylidene)-1,3-thiazolidin-4-one (CAS 551921-81-4)
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- 5-(2-Chlorophenyl)-N-(2-(trifluoromethyl)phenyl)furan-2-carboxamide (CAS 853314-68-8)
- Sitafloxacin impurity 75 (CAS CATO-C4X-115575)
- Tert-butyl 2-(pyridin-2-ylmethylene)hydrazine-1-carboxylate (CAS 328011-57-0)
- 5-Aminoimidazo[4,5-d][1,3]oxazin-7(1H)-one (CAS 130890-45-8)
- N-(4-cyanophenyl)ethane-1-sulfonamide (CAS 1016830-93-5)
- (5-Bromo-6-(piperidin-1-yl)pyridin-3-yl)boronic acid (CAS 2225173-66-8)
- N-methyl-1-(3-(pyrazin-2-yl)-1H-pyrazol-5-yl)methanamine (CAS 1347137-05-6)
- 2-(2-Nitrophenyl)quinazoline (CAS 92151-67-2)
- Phenoxybenzamine EP Impurity A (CAS 902273-13-6)
- N-(2-Cyano-4-nitrophenyl)-2-((3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)thio)acetamide (CAS 750619-17-1)
- (3AR,6aS)-2-(pyridin-4-ylmethyl)octahydropyrrolo[3,4-c]pyrrole (CAS 1689920-09-9)
- Fibrinogen-Binding Inhibitor Peptide (CAS 89105-94-2)
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